Antithrombin III injection via the portal vein suppresses liver damage

Masayuki Miyazaki, Masaki Kato, Masatake Tanaka, Kosuke Tanaka, Shinichiro Takao, Motoyuki Kohjima, Tetsuhide Ito, Munechika Enjoji, Makoto Nakamuta, Kazuhiro Kotoh, Ryoichi Takayanagi

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9 Citations (Scopus)

Abstract

AIM: To investigate the effects of antithrombin III (AT III) injection via the portal vein in acute liver failure. METHODS: Thirty rats were intraperitoneally challenged with lipopolysaccharide (LPS) and D-galactosamine (GalN) and divided into three groups: A control group; a group injected with AT III via the tail vein; and a group injected with AT III via the portal vein. AT III (50 U/kg body weight) was administrated 1 h after challenge with LPS and GalN. Serum levels of inflammatory cytokines and fibrin degradation products, hepatic fibrin deposition, and hepatic mRNA expression of hypoxiarelated hypoxiarelated genes were analyzed. RESULTS: Serum levels of alanine aminotransferase, tumor necrosis factor-α and interleukin-6 decreased significantly following portal vein AT III injection compared with tail vein injection, and control rats. Portal vein AT III injection reduced liver cell destruction and decreased hepatic fibrin deposition. This treatment also significantly reduced hepatic mRNA expression of lactate dehydrogenase and heme oxygenase-1. CONCLUSION: A clinically acceptable dose of AT III injection into the portal vein suppressed liver damage, probably through its enhanced anticoagulant and antiinflammatory activities.

Original languageEnglish
Pages (from-to)1884-1891
Number of pages8
JournalWorld Journal of Gastroenterology
Volume18
Issue number16
DOIs
Publication statusPublished - Apr 28 2012

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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    Miyazaki, M., Kato, M., Tanaka, M., Tanaka, K., Takao, S., Kohjima, M., Ito, T., Enjoji, M., Nakamuta, M., Kotoh, K., & Takayanagi, R. (2012). Antithrombin III injection via the portal vein suppresses liver damage. World Journal of Gastroenterology, 18(16), 1884-1891. https://doi.org/10.3748/wjg.v18.i16.1884