Antithrombin III stimulates prostacyclin production by cultured aortic endothelial cells

Teruaki Yamauchi, Fumio Umeda, Toyoshi Inoguchi, Hajime Nawata

    Research output: Contribution to journalArticle

    122 Citations (Scopus)

    Abstract

    Prostacyclin (PGI2) is a potent vasodilator and an inhibitor of platelet aggregation. We found that antithrombin III (AT III), an anticoagulant present in circulating blood, stimulated PGI2 production by cultured bovine aortic endothelial cells in a dose- and time-dependent manner. The stimulation of PGI2 production by AT III was observed at physiological concentrations and was inhibited by the addition of anti-AT III antiserum and heparin. These results suggest that AT III may stimulate PGI2 production by binding to heparin-like molecules on the endothelial cell membrane.

    Original languageEnglish
    Pages (from-to)1404-1411
    Number of pages8
    JournalBiochemical and Biophysical Research Communications
    Volume163
    Issue number3
    DOIs
    Publication statusPublished - Sep 29 1989

    Fingerprint

    Antithrombin III
    Endothelial cells
    Epoprostenol
    Endothelial Cells
    Heparin
    Platelet Aggregation Inhibitors
    Cell membranes
    Vasodilator Agents
    Anticoagulants
    Immune Sera
    Blood
    Cell Membrane
    Molecules

    All Science Journal Classification (ASJC) codes

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

    Cite this

    Antithrombin III stimulates prostacyclin production by cultured aortic endothelial cells. / Yamauchi, Teruaki; Umeda, Fumio; Inoguchi, Toyoshi; Nawata, Hajime.

    In: Biochemical and Biophysical Research Communications, Vol. 163, No. 3, 29.09.1989, p. 1404-1411.

    Research output: Contribution to journalArticle

    Yamauchi, Teruaki ; Umeda, Fumio ; Inoguchi, Toyoshi ; Nawata, Hajime. / Antithrombin III stimulates prostacyclin production by cultured aortic endothelial cells. In: Biochemical and Biophysical Research Communications. 1989 ; Vol. 163, No. 3. pp. 1404-1411.
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