Antithrombin III stimulates prostacyclin production by cultured aortic endothelial cells

Teruaki Yamauchi, Fumio Umeda, Toyoshi Inoguchi, Hajime Nawata

    Research output: Contribution to journalArticlepeer-review

    127 Citations (Scopus)

    Abstract

    Prostacyclin (PGI2) is a potent vasodilator and an inhibitor of platelet aggregation. We found that antithrombin III (AT III), an anticoagulant present in circulating blood, stimulated PGI2 production by cultured bovine aortic endothelial cells in a dose- and time-dependent manner. The stimulation of PGI2 production by AT III was observed at physiological concentrations and was inhibited by the addition of anti-AT III antiserum and heparin. These results suggest that AT III may stimulate PGI2 production by binding to heparin-like molecules on the endothelial cell membrane.

    Original languageEnglish
    Pages (from-to)1404-1411
    Number of pages8
    JournalBiochemical and Biophysical Research Communications
    Volume163
    Issue number3
    DOIs
    Publication statusPublished - Sep 29 1989

    All Science Journal Classification (ASJC) codes

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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