TY - JOUR
T1 - Antithrombin III stimulates prostacyclin production by cultured aortic endothelial cells
AU - Yamauchi, Teruaki
AU - Umeda, Fumio
AU - Inoguchi, Toyoshi
AU - Nawata, Hajime
PY - 1989/9/29
Y1 - 1989/9/29
N2 - Prostacyclin (PGI2) is a potent vasodilator and an inhibitor of platelet aggregation. We found that antithrombin III (AT III), an anticoagulant present in circulating blood, stimulated PGI2 production by cultured bovine aortic endothelial cells in a dose- and time-dependent manner. The stimulation of PGI2 production by AT III was observed at physiological concentrations and was inhibited by the addition of anti-AT III antiserum and heparin. These results suggest that AT III may stimulate PGI2 production by binding to heparin-like molecules on the endothelial cell membrane.
AB - Prostacyclin (PGI2) is a potent vasodilator and an inhibitor of platelet aggregation. We found that antithrombin III (AT III), an anticoagulant present in circulating blood, stimulated PGI2 production by cultured bovine aortic endothelial cells in a dose- and time-dependent manner. The stimulation of PGI2 production by AT III was observed at physiological concentrations and was inhibited by the addition of anti-AT III antiserum and heparin. These results suggest that AT III may stimulate PGI2 production by binding to heparin-like molecules on the endothelial cell membrane.
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U2 - 10.1016/0006-291X(89)91135-2
DO - 10.1016/0006-291X(89)91135-2
M3 - Article
C2 - 2675842
AN - SCOPUS:0024343069
SN - 0006-291X
VL - 163
SP - 1404
EP - 1411
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -