Antiviral functions of CD8+ cytotoxic T cells in teleost fish

Tomonori Somamoto, Erling Olaf Koppang, Uwe Fischer

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

Cytotoxic T-cells (CTLs) play a pivotal role in eliminating viruses in mammalian adaptive immune system. Many recent studies on T-cell immunity of fish have suggested that teleost CTLs are also important for antiviral immunity. Cellular functional studies using clonal ginbuan crucian carp and rainbow trout have provided in vivo and in vitro evidence that in many respects, virus-specific CTLs of fish have functions similar to those of mammalian CTLs. In addition, mRNA expression profiles of CTL-related molecules, such as CD8, TCR and MHC class I, have shown that in a wide range of fish species, CTLs are involved in antiviral adaptive immunity. These findings are a basis to formulate possible vaccination strategies to trigger effective antiviral CTL responses in teleost fish. This review describes recent advances in our understanding of antiviral CTL functions in teleost fish and discusses vaccination strategies for efficiently inducing CTL activities.

Original languageEnglish
Pages (from-to)197-204
Number of pages8
JournalDevelopmental and Comparative Immunology
Volume43
Issue number2
DOIs
Publication statusPublished - Apr 1 2014

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All Science Journal Classification (ASJC) codes

  • Immunology
  • Developmental Biology

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