Anxa9 gene expression in colorectal cancer: A novel marker for prognosis

Norikatsu Miyoshi, Hirofumi Yamamoto, Koshi Mimori, Shinya Yamashita, Susumu Miyazaki, Sumiko Nakagawa, Hideshi Ishii, Shingo Noura, Masayuki Ohue, Masahiko Yano, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Annexin A9 (ANXA9) is involved with the interaction with membrane phospholipids in a Ca2+-dependent manner. A previous study has shown that ANXA9 expression is associated with bone metastasis in breast cancer, whereas its significance in colorectal cancer (CRC) is unknown. The present study was comprised of 100 patients who underwent surgery for CRC. The correlation between gene expression and the clinical parameters of the patients was assessed. Patients with high ANXA9 expression were statistically susceptible to a relatively worse prognosis, and those with low ANXA9 expression showed improved overall survival compared with those with high expression. In conclusion, the present data suggests that ANXA9 expression is a prognostic factor in CRC patients.

Original languageEnglish
Pages (from-to)2313-2317
Number of pages5
JournalOncology Letters
Volume8
Issue number5
DOIs
Publication statusPublished - Nov 1 2014

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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