Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis

Masaaki Niino, Nobuhiro Mifune, Tatsuo Kohriyama, Masahiro Mori, Takashi Ohashi, Izumi Kawachi, Yuko Shimizu, Hikoaki Fukaura, Ichiro Nakashima, Susumu Kusunoki, Katsuichi Miyamoto, Kazuto Yoshida, Takashi Kanda, Kyoichi Nomura, Takashi Yamamura, Fumihito Yoshii, Jun ichi Kira, Shunya Nakane, Kazumasa Yokoyama, Makoto MatsuiYusei Miyazaki, Seiji Kikuchi

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background: Cognitive impairment could affect quality of life for patients with multiple sclerosis (MS), and cognitive function may be correlated with several factors such as depression and fatigue. This study aimed to evaluate cognitive function in Japanese patients with MS and the association between cognitive function and apathy, fatigue, and depression.Methods: The Brief Repeatable Battery of Neuropsychological tests (BRB-N) was performed in 184 Japanese patients with MS and 163 healthy controls matched for age, gender, and education. The Apathy Scale (AS), Fatigue Questionnaire (FQ), and Beck Depression Inventory Second Edition (BDI-II) were used to evaluate apathy, fatigue, and depression, respectively. Student's t-test was used to compare MS patients and healthy controls. Correlations between two factors were assessed using the Pearson correlation test, and multiple regression analysis was used to evaluate how much each factor affected the BRB-N score.Results: In all BRB-N tests, patients with MS scored significantly lower than controls, and the effect size of symbol digit modalities test was the highest among the 9 tests of the BRB-N. Patients with MS had higher AS (p < 0.001), FQ (p < 0.0001), and BDI-II (p < 0.0001) scores than controls. In patients with MS, scores on most of the BRB-N tests correlated with scores on the AS and BDI-II; however, there was little correlation between scores on the BRB-N tests and those on the FQ.Conclusions: Cognitive function was impaired, particularly information-processing speed, and decreased cognitive function was correlated with apathy and depression in Japanese patients with MS. Despite the association between cognitive variables and depression/apathy, cognitive function was impaired beyond the effect of depression and apathy. However, subjective fatigue is not related with cognitive impairment. Taken together, this suggests that different therapeutic approaches are needed to improve subjective fatigue and cognition, and thereby quality of life, in patients with MS.

Original languageEnglish
Article number3
JournalBMC neurology
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 6 2014

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Apathy
Multiple Sclerosis
Fatigue
Cognition
Depression
Neuropsychological Tests
Quality of Life
Cognitive Dysfunction
Automatic Data Processing
Regression Analysis
Students
Education
Equipment and Supplies

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis. / Niino, Masaaki; Mifune, Nobuhiro; Kohriyama, Tatsuo; Mori, Masahiro; Ohashi, Takashi; Kawachi, Izumi; Shimizu, Yuko; Fukaura, Hikoaki; Nakashima, Ichiro; Kusunoki, Susumu; Miyamoto, Katsuichi; Yoshida, Kazuto; Kanda, Takashi; Nomura, Kyoichi; Yamamura, Takashi; Yoshii, Fumihito; Kira, Jun ichi; Nakane, Shunya; Yokoyama, Kazumasa; Matsui, Makoto; Miyazaki, Yusei; Kikuchi, Seiji.

In: BMC neurology, Vol. 14, No. 1, 3, 06.01.2014.

Research output: Contribution to journalArticle

Niino, M, Mifune, N, Kohriyama, T, Mori, M, Ohashi, T, Kawachi, I, Shimizu, Y, Fukaura, H, Nakashima, I, Kusunoki, S, Miyamoto, K, Yoshida, K, Kanda, T, Nomura, K, Yamamura, T, Yoshii, F, Kira, JI, Nakane, S, Yokoyama, K, Matsui, M, Miyazaki, Y & Kikuchi, S 2014, 'Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis', BMC neurology, vol. 14, no. 1, 3. https://doi.org/10.1186/1471-2377-14-3
Niino, Masaaki ; Mifune, Nobuhiro ; Kohriyama, Tatsuo ; Mori, Masahiro ; Ohashi, Takashi ; Kawachi, Izumi ; Shimizu, Yuko ; Fukaura, Hikoaki ; Nakashima, Ichiro ; Kusunoki, Susumu ; Miyamoto, Katsuichi ; Yoshida, Kazuto ; Kanda, Takashi ; Nomura, Kyoichi ; Yamamura, Takashi ; Yoshii, Fumihito ; Kira, Jun ichi ; Nakane, Shunya ; Yokoyama, Kazumasa ; Matsui, Makoto ; Miyazaki, Yusei ; Kikuchi, Seiji. / Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis. In: BMC neurology. 2014 ; Vol. 14, No. 1.
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abstract = "Background: Cognitive impairment could affect quality of life for patients with multiple sclerosis (MS), and cognitive function may be correlated with several factors such as depression and fatigue. This study aimed to evaluate cognitive function in Japanese patients with MS and the association between cognitive function and apathy, fatigue, and depression.Methods: The Brief Repeatable Battery of Neuropsychological tests (BRB-N) was performed in 184 Japanese patients with MS and 163 healthy controls matched for age, gender, and education. The Apathy Scale (AS), Fatigue Questionnaire (FQ), and Beck Depression Inventory Second Edition (BDI-II) were used to evaluate apathy, fatigue, and depression, respectively. Student's t-test was used to compare MS patients and healthy controls. Correlations between two factors were assessed using the Pearson correlation test, and multiple regression analysis was used to evaluate how much each factor affected the BRB-N score.Results: In all BRB-N tests, patients with MS scored significantly lower than controls, and the effect size of symbol digit modalities test was the highest among the 9 tests of the BRB-N. Patients with MS had higher AS (p < 0.001), FQ (p < 0.0001), and BDI-II (p < 0.0001) scores than controls. In patients with MS, scores on most of the BRB-N tests correlated with scores on the AS and BDI-II; however, there was little correlation between scores on the BRB-N tests and those on the FQ.Conclusions: Cognitive function was impaired, particularly information-processing speed, and decreased cognitive function was correlated with apathy and depression in Japanese patients with MS. Despite the association between cognitive variables and depression/apathy, cognitive function was impaired beyond the effect of depression and apathy. However, subjective fatigue is not related with cognitive impairment. Taken together, this suggests that different therapeutic approaches are needed to improve subjective fatigue and cognition, and thereby quality of life, in patients with MS.",
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T1 - Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis

AU - Niino, Masaaki

AU - Mifune, Nobuhiro

AU - Kohriyama, Tatsuo

AU - Mori, Masahiro

AU - Ohashi, Takashi

AU - Kawachi, Izumi

AU - Shimizu, Yuko

AU - Fukaura, Hikoaki

AU - Nakashima, Ichiro

AU - Kusunoki, Susumu

AU - Miyamoto, Katsuichi

AU - Yoshida, Kazuto

AU - Kanda, Takashi

AU - Nomura, Kyoichi

AU - Yamamura, Takashi

AU - Yoshii, Fumihito

AU - Kira, Jun ichi

AU - Nakane, Shunya

AU - Yokoyama, Kazumasa

AU - Matsui, Makoto

AU - Miyazaki, Yusei

AU - Kikuchi, Seiji

PY - 2014/1/6

Y1 - 2014/1/6

N2 - Background: Cognitive impairment could affect quality of life for patients with multiple sclerosis (MS), and cognitive function may be correlated with several factors such as depression and fatigue. This study aimed to evaluate cognitive function in Japanese patients with MS and the association between cognitive function and apathy, fatigue, and depression.Methods: The Brief Repeatable Battery of Neuropsychological tests (BRB-N) was performed in 184 Japanese patients with MS and 163 healthy controls matched for age, gender, and education. The Apathy Scale (AS), Fatigue Questionnaire (FQ), and Beck Depression Inventory Second Edition (BDI-II) were used to evaluate apathy, fatigue, and depression, respectively. Student's t-test was used to compare MS patients and healthy controls. Correlations between two factors were assessed using the Pearson correlation test, and multiple regression analysis was used to evaluate how much each factor affected the BRB-N score.Results: In all BRB-N tests, patients with MS scored significantly lower than controls, and the effect size of symbol digit modalities test was the highest among the 9 tests of the BRB-N. Patients with MS had higher AS (p < 0.001), FQ (p < 0.0001), and BDI-II (p < 0.0001) scores than controls. In patients with MS, scores on most of the BRB-N tests correlated with scores on the AS and BDI-II; however, there was little correlation between scores on the BRB-N tests and those on the FQ.Conclusions: Cognitive function was impaired, particularly information-processing speed, and decreased cognitive function was correlated with apathy and depression in Japanese patients with MS. Despite the association between cognitive variables and depression/apathy, cognitive function was impaired beyond the effect of depression and apathy. However, subjective fatigue is not related with cognitive impairment. Taken together, this suggests that different therapeutic approaches are needed to improve subjective fatigue and cognition, and thereby quality of life, in patients with MS.

AB - Background: Cognitive impairment could affect quality of life for patients with multiple sclerosis (MS), and cognitive function may be correlated with several factors such as depression and fatigue. This study aimed to evaluate cognitive function in Japanese patients with MS and the association between cognitive function and apathy, fatigue, and depression.Methods: The Brief Repeatable Battery of Neuropsychological tests (BRB-N) was performed in 184 Japanese patients with MS and 163 healthy controls matched for age, gender, and education. The Apathy Scale (AS), Fatigue Questionnaire (FQ), and Beck Depression Inventory Second Edition (BDI-II) were used to evaluate apathy, fatigue, and depression, respectively. Student's t-test was used to compare MS patients and healthy controls. Correlations between two factors were assessed using the Pearson correlation test, and multiple regression analysis was used to evaluate how much each factor affected the BRB-N score.Results: In all BRB-N tests, patients with MS scored significantly lower than controls, and the effect size of symbol digit modalities test was the highest among the 9 tests of the BRB-N. Patients with MS had higher AS (p < 0.001), FQ (p < 0.0001), and BDI-II (p < 0.0001) scores than controls. In patients with MS, scores on most of the BRB-N tests correlated with scores on the AS and BDI-II; however, there was little correlation between scores on the BRB-N tests and those on the FQ.Conclusions: Cognitive function was impaired, particularly information-processing speed, and decreased cognitive function was correlated with apathy and depression in Japanese patients with MS. Despite the association between cognitive variables and depression/apathy, cognitive function was impaired beyond the effect of depression and apathy. However, subjective fatigue is not related with cognitive impairment. Taken together, this suggests that different therapeutic approaches are needed to improve subjective fatigue and cognition, and thereby quality of life, in patients with MS.

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DO - 10.1186/1471-2377-14-3

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