TY - JOUR
T1 - Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men
AU - Shinomiya, Sachiko
AU - Sasaki, Jun
AU - Kiyohara, Chikako
AU - Tsuji, Emiko
AU - Inoue, Hisako
AU - Marugame, Tomomi
AU - Handa, Koichi
AU - Hayabuchi, Hitomi
AU - Hamada, Hiroaki
AU - Eguchi, Hiroyuki
AU - Fukushima, Yoshitaka
AU - Kono, Suminori
N1 - Funding Information:
The authors are grateful to the ward nurses of the SDF Fukuoka Hospital for their co-operation. This study was supported in part by Grants-in-Aid from the Japan Society for the Promotion of Science (12470098 to SK) and from the Ministry of Health and Welfare, Japan.
PY - 2001/3/10
Y1 - 2001/3/10
N2 - We examined the relation of serum lipids and apolipoprotein E genotype to colorectal adenomas among 205 cases and 220 controls with normal colonoscopy in Japanese men. With adjustment for body mass index, cigarette smoking, alcohol use, and other covaiates, odds ratios of proximal and distal adenomas associated with the presence of an allele ε4 were 0.59 (95% confidence interval 0.23-1.45) and 0.99 (0.50-1.98), respectively. While serum total and LDL cholesterol were unrelated to both proximal and distal adenomas, serum triglycerides were positively related to distal adenomas. The findings suggest that altered lipid metabolism may be differentially associated with tumorigenesis in the proximal and distal colorectum.
AB - We examined the relation of serum lipids and apolipoprotein E genotype to colorectal adenomas among 205 cases and 220 controls with normal colonoscopy in Japanese men. With adjustment for body mass index, cigarette smoking, alcohol use, and other covaiates, odds ratios of proximal and distal adenomas associated with the presence of an allele ε4 were 0.59 (95% confidence interval 0.23-1.45) and 0.99 (0.50-1.98), respectively. While serum total and LDL cholesterol were unrelated to both proximal and distal adenomas, serum triglycerides were positively related to distal adenomas. The findings suggest that altered lipid metabolism may be differentially associated with tumorigenesis in the proximal and distal colorectum.
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U2 - 10.1016/S0304-3835(00)00724-2
DO - 10.1016/S0304-3835(00)00724-2
M3 - Article
C2 - 11166913
AN - SCOPUS:0035836075
VL - 164
SP - 33
EP - 40
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1
ER -
