Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men

Sachiko Shinomiya; Jun Sasaki; Chikako Kiyohara; Emiko Tsuji; Hisako Inoue; Tomomi Marugame; Koichi Handa; Hitomi Hayabuchi; Hiroaki Hamada; Hiroyuki Eguchi; Yoshitaka Fukushima; Suminori Kono

doi:10.1016/S0304-3835(00)00724-2

Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men

Sachiko Shinomiya, Jun Sasaki, Chikako Kiyohara, Emiko Tsuji, Hisako Inoue, Tomomi Marugame, Koichi Handa, Hitomi Hayabuchi, Hiroaki Hamada, Hiroyuki Eguchi, Yoshitaka Fukushima, Suminori Kono

Social Medicine

Research output: Contribution to journal › Article

24 Citations (Scopus)

Abstract

We examined the relation of serum lipids and apolipoprotein E genotype to colorectal adenomas among 205 cases and 220 controls with normal colonoscopy in Japanese men. With adjustment for body mass index, cigarette smoking, alcohol use, and other covaiates, odds ratios of proximal and distal adenomas associated with the presence of an allele ε4 were 0.59 (95% confidence interval 0.23-1.45) and 0.99 (0.50-1.98), respectively. While serum total and LDL cholesterol were unrelated to both proximal and distal adenomas, serum triglycerides were positively related to distal adenomas. The findings suggest that altered lipid metabolism may be differentially associated with tumorigenesis in the proximal and distal colorectum.

Original language	English
Pages (from-to)	33-40
Number of pages	8
Journal	Cancer Letters
Volume	164
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(00)00724-2
Publication status	Published - Mar 10 2001

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Access to Document

10.1016/S0304-3835(00)00724-2

Fingerprint Dive into the research topics of 'Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men'. Together they form a unique fingerprint.

Cite this

Shinomiya, S., Sasaki, J., Kiyohara, C., Tsuji, E., Inoue, H., Marugame, T., Handa, K., Hayabuchi, H., Hamada, H., Eguchi, H., Fukushima, Y., & Kono, S. (2001). Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men. Cancer Letters, 164(1), 33-40. https://doi.org/10.1016/S0304-3835(00)00724-2

Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men. / Shinomiya, Sachiko; Sasaki, Jun; Kiyohara, Chikako; Tsuji, Emiko; Inoue, Hisako; Marugame, Tomomi; Handa, Koichi; Hayabuchi, Hitomi; Hamada, Hiroaki; Eguchi, Hiroyuki; Fukushima, Yoshitaka; Kono, Suminori.

In: Cancer Letters, Vol. 164, No. 1, 10.03.2001, p. 33-40.

Research output: Contribution to journal › Article

@article{7f48c1324631409081fb736b36af73f7,

title = "Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men",

abstract = "We examined the relation of serum lipids and apolipoprotein E genotype to colorectal adenomas among 205 cases and 220 controls with normal colonoscopy in Japanese men. With adjustment for body mass index, cigarette smoking, alcohol use, and other covaiates, odds ratios of proximal and distal adenomas associated with the presence of an allele ε4 were 0.59 (95% confidence interval 0.23-1.45) and 0.99 (0.50-1.98), respectively. While serum total and LDL cholesterol were unrelated to both proximal and distal adenomas, serum triglycerides were positively related to distal adenomas. The findings suggest that altered lipid metabolism may be differentially associated with tumorigenesis in the proximal and distal colorectum.",

author = "Sachiko Shinomiya and Jun Sasaki and Chikako Kiyohara and Emiko Tsuji and Hisako Inoue and Tomomi Marugame and Koichi Handa and Hitomi Hayabuchi and Hiroaki Hamada and Hiroyuki Eguchi and Yoshitaka Fukushima and Suminori Kono",

year = "2001",

month = mar,

day = "10",

doi = "10.1016/S0304-3835(00)00724-2",

language = "English",

volume = "164",

pages = "33--40",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men

AU - Shinomiya, Sachiko

AU - Sasaki, Jun

AU - Kiyohara, Chikako

AU - Tsuji, Emiko

AU - Inoue, Hisako

AU - Marugame, Tomomi

AU - Handa, Koichi

AU - Hayabuchi, Hitomi

AU - Hamada, Hiroaki

AU - Eguchi, Hiroyuki

AU - Fukushima, Yoshitaka

AU - Kono, Suminori

PY - 2001/3/10

Y1 - 2001/3/10

N2 - We examined the relation of serum lipids and apolipoprotein E genotype to colorectal adenomas among 205 cases and 220 controls with normal colonoscopy in Japanese men. With adjustment for body mass index, cigarette smoking, alcohol use, and other covaiates, odds ratios of proximal and distal adenomas associated with the presence of an allele ε4 were 0.59 (95% confidence interval 0.23-1.45) and 0.99 (0.50-1.98), respectively. While serum total and LDL cholesterol were unrelated to both proximal and distal adenomas, serum triglycerides were positively related to distal adenomas. The findings suggest that altered lipid metabolism may be differentially associated with tumorigenesis in the proximal and distal colorectum.

AB - We examined the relation of serum lipids and apolipoprotein E genotype to colorectal adenomas among 205 cases and 220 controls with normal colonoscopy in Japanese men. With adjustment for body mass index, cigarette smoking, alcohol use, and other covaiates, odds ratios of proximal and distal adenomas associated with the presence of an allele ε4 were 0.59 (95% confidence interval 0.23-1.45) and 0.99 (0.50-1.98), respectively. While serum total and LDL cholesterol were unrelated to both proximal and distal adenomas, serum triglycerides were positively related to distal adenomas. The findings suggest that altered lipid metabolism may be differentially associated with tumorigenesis in the proximal and distal colorectum.

UR - http://www.scopus.com/inward/record.url?scp=0035836075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035836075&partnerID=8YFLogxK

U2 - 10.1016/S0304-3835(00)00724-2

DO - 10.1016/S0304-3835(00)00724-2

M3 - Article

C2 - 11166913

AN - SCOPUS:0035836075

VL - 164

SP - 33

EP - 40

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1

ER -