Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men

Sachiko Shinomiya, Jun Sasaki, Chikako Kiyohara, Emiko Tsuji, Hisako Inoue, Tomomi Marugame, Koichi Handa, Hitomi Hayabuchi, Hiroaki Hamada, Hiroyuki Eguchi, Yoshitaka Fukushima, Suminori Kono

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Abstract

We examined the relation of serum lipids and apolipoprotein E genotype to colorectal adenomas among 205 cases and 220 controls with normal colonoscopy in Japanese men. With adjustment for body mass index, cigarette smoking, alcohol use, and other covaiates, odds ratios of proximal and distal adenomas associated with the presence of an allele ε4 were 0.59 (95% confidence interval 0.23-1.45) and 0.99 (0.50-1.98), respectively. While serum total and LDL cholesterol were unrelated to both proximal and distal adenomas, serum triglycerides were positively related to distal adenomas. The findings suggest that altered lipid metabolism may be differentially associated with tumorigenesis in the proximal and distal colorectum.

Original languageEnglish
Pages (from-to)33-40
Number of pages8
JournalCancer Letters
Volume164
Issue number1
DOIs
Publication statusPublished - Mar 10 2001

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Shinomiya, S., Sasaki, J., Kiyohara, C., Tsuji, E., Inoue, H., Marugame, T., Handa, K., Hayabuchi, H., Hamada, H., Eguchi, H., Fukushima, Y., & Kono, S. (2001). Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men. Cancer Letters, 164(1), 33-40. https://doi.org/10.1016/S0304-3835(00)00724-2