Apoptosis by CD95 (Fas)-dependent and -independent mechanisms in Peyer's patch lymphocytes in murine retrovirus-induced immunodeficiency syndrome

Jun Usami, Kenji Hiromatsu, Yoshiyasu Aoki, Noritada Kobayashi, Masahiko Makino, Hideo Yagita, Yoshihiro Matsumoto, Kenji Maeda, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    CD95 (Fas)/CD95 ligand (CD95 L)-mediated apoptosis is thought to be involved in the delayed progression of murine AIDS (MAIDS) induced by LP-BM5 murine leukemia virus (MuLV). We show evidence of apoptosis in lymphocytes of Peyer's patches (PP) at the early stage of MAIDS. Both T and B cells in PP expressed CD95 at the early stage of MAIDS and decreased in number thereafter. The decrease in T cells was not evident in CD95-mutated lpr mice with MAIDS, suggesting that CD95/CD95 L interaction is involved in the apoptosis of T cells in PP during the course of MAIDS. On the other hand, the number of B cells was also decreased in PP of lpr mice with MAIDS. The proliferative ability of B cells in PP of MAIDS mice in response to immunoglobulin M cross-linking or lipopolysaccharide was severely impaired, while the B cells normally proliferated in response to anti-CD40 monoclonal antibody. These findings imply that aberrantly activated B cells in PP undergo apoptosis independently of the CD95/CD95 L system during the course of infection with MAIDS virus.

    Original languageEnglish
    Pages (from-to)8917-8925
    Number of pages9
    JournalJournal of virology
    Volume70
    Issue number12
    Publication statusPublished - Dec 1 1996

    Fingerprint

    Retroviridae
    Murine Acquired Immunodeficiency Syndrome
    Peyer's Patches
    Peyer's patches
    immunosuppression
    lymphocytes
    apoptosis
    Lymphocytes
    Apoptosis
    mice
    B-Lymphocytes
    B-lymphocytes
    Fas Ligand Protein
    T-Lymphocytes
    T-lymphocytes
    Murine Leukemia Viruses
    Murine leukemia virus
    immunoglobulin M
    Immunoglobulin M
    Lipopolysaccharides

    All Science Journal Classification (ASJC) codes

    • Microbiology
    • Immunology
    • Insect Science
    • Virology

    Cite this

    Usami, J., Hiromatsu, K., Aoki, Y., Kobayashi, N., Makino, M., Yagita, H., ... Yoshikai, Y. (1996). Apoptosis by CD95 (Fas)-dependent and -independent mechanisms in Peyer's patch lymphocytes in murine retrovirus-induced immunodeficiency syndrome. Journal of virology, 70(12), 8917-8925.

    Apoptosis by CD95 (Fas)-dependent and -independent mechanisms in Peyer's patch lymphocytes in murine retrovirus-induced immunodeficiency syndrome. / Usami, Jun; Hiromatsu, Kenji; Aoki, Yoshiyasu; Kobayashi, Noritada; Makino, Masahiko; Yagita, Hideo; Matsumoto, Yoshihiro; Maeda, Kenji; Yoshikai, Yasunobu.

    In: Journal of virology, Vol. 70, No. 12, 01.12.1996, p. 8917-8925.

    Research output: Contribution to journalArticle

    Usami, J, Hiromatsu, K, Aoki, Y, Kobayashi, N, Makino, M, Yagita, H, Matsumoto, Y, Maeda, K & Yoshikai, Y 1996, 'Apoptosis by CD95 (Fas)-dependent and -independent mechanisms in Peyer's patch lymphocytes in murine retrovirus-induced immunodeficiency syndrome', Journal of virology, vol. 70, no. 12, pp. 8917-8925.
    Usami, Jun ; Hiromatsu, Kenji ; Aoki, Yoshiyasu ; Kobayashi, Noritada ; Makino, Masahiko ; Yagita, Hideo ; Matsumoto, Yoshihiro ; Maeda, Kenji ; Yoshikai, Yasunobu. / Apoptosis by CD95 (Fas)-dependent and -independent mechanisms in Peyer's patch lymphocytes in murine retrovirus-induced immunodeficiency syndrome. In: Journal of virology. 1996 ; Vol. 70, No. 12. pp. 8917-8925.
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    abstract = "CD95 (Fas)/CD95 ligand (CD95 L)-mediated apoptosis is thought to be involved in the delayed progression of murine AIDS (MAIDS) induced by LP-BM5 murine leukemia virus (MuLV). We show evidence of apoptosis in lymphocytes of Peyer's patches (PP) at the early stage of MAIDS. Both T and B cells in PP expressed CD95 at the early stage of MAIDS and decreased in number thereafter. The decrease in T cells was not evident in CD95-mutated lpr mice with MAIDS, suggesting that CD95/CD95 L interaction is involved in the apoptosis of T cells in PP during the course of MAIDS. On the other hand, the number of B cells was also decreased in PP of lpr mice with MAIDS. The proliferative ability of B cells in PP of MAIDS mice in response to immunoglobulin M cross-linking or lipopolysaccharide was severely impaired, while the B cells normally proliferated in response to anti-CD40 monoclonal antibody. These findings imply that aberrantly activated B cells in PP undergo apoptosis independently of the CD95/CD95 L system during the course of infection with MAIDS virus.",
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    AU - Makino, Masahiko

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