Apoptosis signaling pathways in lung diseases.

K. Kuwano, M. Yoshimi, T. Maeyama, N. Hamada, M. Yamada, Y. Nakanishi

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Evidence that apoptosis plays an important role in the pathophysiology of lung diseases has been accumulated. Apoptosis signaling is classically composed of two principle pathways. One is a direct pathway from death receptor ligation to caspase cascade activation and cell death. Death receptor ligation triggers recruitment of the precursor form of caspase-8 to a death-inducing complex, through the adaptor protein FADD, which leads to caspase-8 activation. The other pathway triggered by stimuli such as drugs, radiation, infectious agents and reactive oxygen species is initiated in mitochondria. After cytochrome c is released into the cytosol from the mitochondria, it binds to Apaf1 and ATP, which then activate caspase-9. Recently, endoplasmic reticulum has also been shown to be the organelle to execute apoptosis. Further understanding of molecular mechanisms of apoptosis and its regulation by novel drugs may lead to the development of effective strategies against lung diseases. We overview the signaling pathways of apoptosis and discuss the involvement of apoptosis in the pathophysiology of various lung diseases.

Original languageEnglish
Pages (from-to)49-56
Number of pages8
JournalMedicinal chemistry
Volume1
Issue number1
DOIs
Publication statusPublished - Jan 2005

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Lung Diseases
Apoptosis
Death Domain Receptors
Caspase 8
Ligation
Mitochondria
Caspase 9
Drug and Narcotic Control
Caspases
Cytochromes c
Endoplasmic Reticulum
Organelles
Cytosol
Reactive Oxygen Species
Cell Death
Adenosine Triphosphate
Radiation
Pharmaceutical Preparations
Proteins

All Science Journal Classification (ASJC) codes

  • Drug Discovery

Cite this

Kuwano, K., Yoshimi, M., Maeyama, T., Hamada, N., Yamada, M., & Nakanishi, Y. (2005). Apoptosis signaling pathways in lung diseases. Medicinal chemistry, 1(1), 49-56. https://doi.org/10.2174/1573406053402497

Apoptosis signaling pathways in lung diseases. / Kuwano, K.; Yoshimi, M.; Maeyama, T.; Hamada, N.; Yamada, M.; Nakanishi, Y.

In: Medicinal chemistry, Vol. 1, No. 1, 01.2005, p. 49-56.

Research output: Contribution to journalReview article

Kuwano, K, Yoshimi, M, Maeyama, T, Hamada, N, Yamada, M & Nakanishi, Y 2005, 'Apoptosis signaling pathways in lung diseases.', Medicinal chemistry, vol. 1, no. 1, pp. 49-56. https://doi.org/10.2174/1573406053402497
Kuwano K, Yoshimi M, Maeyama T, Hamada N, Yamada M, Nakanishi Y. Apoptosis signaling pathways in lung diseases. Medicinal chemistry. 2005 Jan;1(1):49-56. https://doi.org/10.2174/1573406053402497
Kuwano, K. ; Yoshimi, M. ; Maeyama, T. ; Hamada, N. ; Yamada, M. ; Nakanishi, Y. / Apoptosis signaling pathways in lung diseases. In: Medicinal chemistry. 2005 ; Vol. 1, No. 1. pp. 49-56.
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