Apparent diffusion coefficient characteristics of various adrenal tumors

Tomoyuki Hida, Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Yasuhiro Ushijima, Yukihisa Takayama, Nobuhiro Fujita, Dai Shimamoto, Akira Yokomizo, Katsunori Tatsugami, Junichi Inokuchi, Yuichiro Kubo, Hiroshi Honda

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: Using pathologically proven tumors and 3 methods of apparent diffusion coefficient (ADC) measurement, we examined the potential of diffusion-weighted imaging (DWI) to differentiate adrenal tumors.

Methods: We evaluated adrenal tumors of 52 patients who underwent magnetic resonance (MR) examination including DWI and adrenal resection or biopsy between July 2006 and August 2011. Tumors included 25 cortical adenomas, 14 pheochromocytomas, 6 adrenal metastases, and seven others. We defined the tumor’s “solid” region as an enhancing area on contrast-enhanced MR or computed tomography (CT) and measured the ADC of the tumor’s “entire” and “solid” regions within a region of interest (ROI) placed on an ADC map (“entire” and “solid” ADCs). We obtained a “minimum” ADC by placing an ROI in an area showing the lowest ADC within the “solid” region. We also calculated the ratio of “non-solid” area to “entire” tumor and compared the average “entire,” “solid,” and “minimum” ADCs and the ratio of “non-solid” area to “entire” tumor between benign and malignant groups.

Results: The average “entire” ADC was significantly higher for the benign (1.35 ± 0.38 × 10-3mm2/s) than malignant group (1.01 ± 0.17 × 10-3mm2/s), and the average “solid” and “minimum” ADC and the ratio of “non-solid” area to “entire” tumor did not differ significantly between the benign and malignant groups.

Conclusion: The higher “entire” ADC value of the benign group, which might be obtained incidentally, can be considered dependent on the condition of necrosis, hemorrhage, and degeneration. ADC measurement of a tumor’s “solid” region was not useful for differentiating pathologically proven adrenal tumors.

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalMagnetic Resonance in Medical Sciences
Volume13
Issue number3
DOIs
Publication statusPublished - Sep 29 2014

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Glandular and Epithelial Neoplasms
Neoplasms
Magnetic Resonance Spectroscopy
Pheochromocytoma
Adenoma
Necrosis
Tomography
Hemorrhage
Neoplasm Metastasis
Biopsy

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Apparent diffusion coefficient characteristics of various adrenal tumors. / Hida, Tomoyuki; Nishie, Akihiro; Asayama, Yoshiki; Ishigami, Kousei; Ushijima, Yasuhiro; Takayama, Yukihisa; Fujita, Nobuhiro; Shimamoto, Dai; Yokomizo, Akira; Tatsugami, Katsunori; Inokuchi, Junichi; Kubo, Yuichiro; Honda, Hiroshi.

In: Magnetic Resonance in Medical Sciences, Vol. 13, No. 3, 29.09.2014, p. 183-189.

Research output: Contribution to journalArticle

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abstract = "Purpose: Using pathologically proven tumors and 3 methods of apparent diffusion coefficient (ADC) measurement, we examined the potential of diffusion-weighted imaging (DWI) to differentiate adrenal tumors.Methods: We evaluated adrenal tumors of 52 patients who underwent magnetic resonance (MR) examination including DWI and adrenal resection or biopsy between July 2006 and August 2011. Tumors included 25 cortical adenomas, 14 pheochromocytomas, 6 adrenal metastases, and seven others. We defined the tumor’s “solid” region as an enhancing area on contrast-enhanced MR or computed tomography (CT) and measured the ADC of the tumor’s “entire” and “solid” regions within a region of interest (ROI) placed on an ADC map (“entire” and “solid” ADCs). We obtained a “minimum” ADC by placing an ROI in an area showing the lowest ADC within the “solid” region. We also calculated the ratio of “non-solid” area to “entire” tumor and compared the average “entire,” “solid,” and “minimum” ADCs and the ratio of “non-solid” area to “entire” tumor between benign and malignant groups.Results: The average “entire” ADC was significantly higher for the benign (1.35 ± 0.38 × 10-3mm2/s) than malignant group (1.01 ± 0.17 × 10-3mm2/s), and the average “solid” and “minimum” ADC and the ratio of “non-solid” area to “entire” tumor did not differ significantly between the benign and malignant groups.Conclusion: The higher “entire” ADC value of the benign group, which might be obtained incidentally, can be considered dependent on the condition of necrosis, hemorrhage, and degeneration. ADC measurement of a tumor’s “solid” region was not useful for differentiating pathologically proven adrenal tumors.",
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AU - Hida, Tomoyuki

AU - Nishie, Akihiro

AU - Asayama, Yoshiki

AU - Ishigami, Kousei

AU - Ushijima, Yasuhiro

AU - Takayama, Yukihisa

AU - Fujita, Nobuhiro

AU - Shimamoto, Dai

AU - Yokomizo, Akira

AU - Tatsugami, Katsunori

AU - Inokuchi, Junichi

AU - Kubo, Yuichiro

AU - Honda, Hiroshi

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