Appearance of focal cortical dysplasia on serial MRI after maturation of myelination

Fumiaki Yoshida; Takato Morioka; Kimiaki Hashiguchi; Yasushi Miyagi; Shinji Nagata; Yui Yamaguchi; Masaharu Ohfu; Tomio Sasaki

doi:10.1007/s00381-007-0447-x

Appearance of focal cortical dysplasia on serial MRI after maturation of myelination

Fumiaki Yoshida, Takato Morioka, Kimiaki Hashiguchi, Yasushi Miyagi, Shinji Nagata, Yui Yamaguchi, Masaharu Ohfu, Tomio Sasaki

Neurosurgery

Research output: Contribution to journal › Article

8 Citations (Scopus)

Abstract

Case report: It is well known that magnetic resonance imaging (MRI) findings of focal cortical dysplasia (FCD) can change with maturation of myelination. In this paper, we report a patient with intractable epilepsy and negative MRI at the age of 2.5 years, after completion of myelination. Follow-up MRI at the age of 6 years revealed typical FCD findings in the right frontal lobe. During these 3.5 years, electroencephalogram (EEG) consistently depicted an area of irritation in accordance with de novo MRI findings. Intraoperative electrocorticogram showed frequent paroxysmal activity in the right frontal lobe; excision of the epileptogenic cortex resulted in a reduction in seizures. Conclusion: It is possible that FCD becomes apparent on MRI even after maturation of myelination; thus, repeated MRI is recommended while EEG continues to demonstrate focal findings.

Original language	English
Pages (from-to)	269-273
Number of pages	5
Journal	Child's Nervous System
Volume	24
Issue number	2
DOIs	https://doi.org/10.1007/s00381-007-0447-x
Publication status	Published - Feb 2008

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Clinical Neurology

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Yoshida, F., Morioka, T., Hashiguchi, K., Miyagi, Y., Nagata, S., Yamaguchi, Y., Ohfu, M., & Sasaki, T. (2008). Appearance of focal cortical dysplasia on serial MRI after maturation of myelination. Child's Nervous System, 24(2), 269-273. https://doi.org/10.1007/s00381-007-0447-x

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title = "Appearance of focal cortical dysplasia on serial MRI after maturation of myelination",

abstract = "Case report: It is well known that magnetic resonance imaging (MRI) findings of focal cortical dysplasia (FCD) can change with maturation of myelination. In this paper, we report a patient with intractable epilepsy and negative MRI at the age of 2.5 years, after completion of myelination. Follow-up MRI at the age of 6 years revealed typical FCD findings in the right frontal lobe. During these 3.5 years, electroencephalogram (EEG) consistently depicted an area of irritation in accordance with de novo MRI findings. Intraoperative electrocorticogram showed frequent paroxysmal activity in the right frontal lobe; excision of the epileptogenic cortex resulted in a reduction in seizures. Conclusion: It is possible that FCD becomes apparent on MRI even after maturation of myelination; thus, repeated MRI is recommended while EEG continues to demonstrate focal findings.",

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AU - Yoshida, Fumiaki

AU - Morioka, Takato

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AU - Miyagi, Yasushi

AU - Nagata, Shinji

AU - Yamaguchi, Yui

AU - Ohfu, Masaharu

AU - Sasaki, Tomio

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N2 - Case report: It is well known that magnetic resonance imaging (MRI) findings of focal cortical dysplasia (FCD) can change with maturation of myelination. In this paper, we report a patient with intractable epilepsy and negative MRI at the age of 2.5 years, after completion of myelination. Follow-up MRI at the age of 6 years revealed typical FCD findings in the right frontal lobe. During these 3.5 years, electroencephalogram (EEG) consistently depicted an area of irritation in accordance with de novo MRI findings. Intraoperative electrocorticogram showed frequent paroxysmal activity in the right frontal lobe; excision of the epileptogenic cortex resulted in a reduction in seizures. Conclusion: It is possible that FCD becomes apparent on MRI even after maturation of myelination; thus, repeated MRI is recommended while EEG continues to demonstrate focal findings.

AB - Case report: It is well known that magnetic resonance imaging (MRI) findings of focal cortical dysplasia (FCD) can change with maturation of myelination. In this paper, we report a patient with intractable epilepsy and negative MRI at the age of 2.5 years, after completion of myelination. Follow-up MRI at the age of 6 years revealed typical FCD findings in the right frontal lobe. During these 3.5 years, electroencephalogram (EEG) consistently depicted an area of irritation in accordance with de novo MRI findings. Intraoperative electrocorticogram showed frequent paroxysmal activity in the right frontal lobe; excision of the epileptogenic cortex resulted in a reduction in seizures. Conclusion: It is possible that FCD becomes apparent on MRI even after maturation of myelination; thus, repeated MRI is recommended while EEG continues to demonstrate focal findings.

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