Application of bioinformatics for DNA microarray data to bioscience, bioengineering and medical fields

Taizo Hanai, Hiroyuki Hamada, Masahiro Okamoto

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

In the 1990s, DNA microarray or DNA chip as a novel biological experimental technology was developed, which enables the comprehensive measurement of the expression levels of hundreds of genes, simultaneously. Using this technique, a comprehensive understanding of the cell can be achieved. However, because even simple life forms, such as microorganisms, have more than a thousand kinds of genes, the data from a DNA chip cannot be analyzed without statistical and informational technology. Bioinformatics is the interdisciplinary research field integrating molecular biology with informatics, and it is expected to have a huge impact on the bioscientific, bioengineering and medical fields. There are many techniques in bioinformatics for the analysis of DNA microarray data; however, these are mainly divided into fold-change analysis, clustering, classification, genetic network analysis, and simulation. In this review, these techniques are briefly explained by using some examples.

Original languageEnglish
Pages (from-to)377-384
Number of pages8
JournalJournal of Bioscience and Bioengineering
Volume101
Issue number5
DOIs
Publication statusPublished - May 1 2006

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Bioengineering
Biomedical engineering
Bioinformatics
Microarrays
Oligonucleotide Array Sequence Analysis
Computational Biology
DNA
Genes
Technology
Informatics
Molecular biology
Electric network analysis
Microorganisms
Cluster Analysis
Molecular Biology
Research

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Cite this

Application of bioinformatics for DNA microarray data to bioscience, bioengineering and medical fields. / Hanai, Taizo; Hamada, Hiroyuki; Okamoto, Masahiro.

In: Journal of Bioscience and Bioengineering, Vol. 101, No. 5, 01.05.2006, p. 377-384.

Research output: Contribution to journalArticle

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