Application of liver transplantation for familial amyloid polyneuropathy combined with crohn's disease

Toru Ikegami, T. Nishizaki, K. Yanaga, K. Nomoto, R. Ohta, K. Kawamoto, K. Masuda, K. Sugimachi

Research output: Contribution to journalArticle

Abstract

We describe the case of a 31-year-old Japanese man with familial amyloid polyneuropathy combined with Crohn's disease, who underwent living-related orthotopic liver transplantation. Although he had a 2-year history of alternating constipation/diarrhea, his bowel symptoms exacerbated severely during the period he was in our ward for pretransplant evaluation. Small bowel barium examination and gastroduodenal endoscopy showed typical features of Crohn's disease. He was diagnosed as having active Crohn's disease, and the scheduled living-related orthotopic liver transplantation was postponed. After controlling the active disease with conservative therapy for two months, he underwent living-related orthotopic liver transplantation using a graft of the left lobe from his father. Postoperative medication consisted of azathioprine, aminosalicylates, tacrolimus and steroids. His postoperative course was uneventful, and he was discharged from hospital on the 25th postoperative day. Pre- and postoperative transplant management of patients with Crohn's disease is also discussed, because it influences the clinical course of inflammatory bowel diseases.

Original languageEnglish
Pages (from-to)844-846
Number of pages3
JournalHepato-Gastroenterology
Volume48
Issue number39
Publication statusPublished - Jul 18 2001

Fingerprint

Familial Amyloid Neuropathies
Crohn Disease
Liver Transplantation
Transplants
Azathioprine
Tacrolimus
Barium
Constipation
Inflammatory Bowel Diseases
Fathers
Endoscopy
Diarrhea
Steroids

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Ikegami, T., Nishizaki, T., Yanaga, K., Nomoto, K., Ohta, R., Kawamoto, K., ... Sugimachi, K. (2001). Application of liver transplantation for familial amyloid polyneuropathy combined with crohn's disease. Hepato-Gastroenterology, 48(39), 844-846.

Application of liver transplantation for familial amyloid polyneuropathy combined with crohn's disease. / Ikegami, Toru; Nishizaki, T.; Yanaga, K.; Nomoto, K.; Ohta, R.; Kawamoto, K.; Masuda, K.; Sugimachi, K.

In: Hepato-Gastroenterology, Vol. 48, No. 39, 18.07.2001, p. 844-846.

Research output: Contribution to journalArticle

Ikegami, T, Nishizaki, T, Yanaga, K, Nomoto, K, Ohta, R, Kawamoto, K, Masuda, K & Sugimachi, K 2001, 'Application of liver transplantation for familial amyloid polyneuropathy combined with crohn's disease', Hepato-Gastroenterology, vol. 48, no. 39, pp. 844-846.
Ikegami T, Nishizaki T, Yanaga K, Nomoto K, Ohta R, Kawamoto K et al. Application of liver transplantation for familial amyloid polyneuropathy combined with crohn's disease. Hepato-Gastroenterology. 2001 Jul 18;48(39):844-846.
Ikegami, Toru ; Nishizaki, T. ; Yanaga, K. ; Nomoto, K. ; Ohta, R. ; Kawamoto, K. ; Masuda, K. ; Sugimachi, K. / Application of liver transplantation for familial amyloid polyneuropathy combined with crohn's disease. In: Hepato-Gastroenterology. 2001 ; Vol. 48, No. 39. pp. 844-846.
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