Application of schizophyllan as a novel gene carrier.

K. Sakurai; T. Kimura; K. Koumoto; M. Mizu; R. Kobayashi; S. Shinkai

doi:10.1093/nass/1.1.223

Application of schizophyllan as a novel gene carrier.

K. Sakurai, T. Kimura, K. Koumoto, M. Mizu, R. Kobayashi, S. Shinkai

Research output: Contribution to journal › Article

8 Citations (Scopus)

Abstract

Schizophyllan (SPG) is a kind of beta-1,3-glucan which has glucose side chain through a beta-1,6-glycosil bond (Fig. 1). It was found that SPG could form complex with single stranded polynucleotides. SPG forms triple stranded complex with single stranded RNAs thorough hydrogen bonding and hydrophobic interaction. It was found tht polynucleotide was protected from nuclease attacking to form the complex with SPG, and SPG enhanced antisense efficient.

Original language	English
Pages (from-to)	223-224
Number of pages	2
Journal	Nucleic acids research. Supplement (2001)
Issue number	1
DOIs	https://doi.org/10.1093/nass/1.1.223
Publication status	Published - 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1093/nass/1.1.223

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Sakurai, K., Kimura, T., Koumoto, K., Mizu, M., Kobayashi, R., & Shinkai, S. (2001). Application of schizophyllan as a novel gene carrier. Nucleic acids research. Supplement (2001), (1), 223-224. https://doi.org/10.1093/nass/1.1.223

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AU - Koumoto, K.

AU - Mizu, M.

AU - Kobayashi, R.

AU - Shinkai, S.

PY - 2001

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