Abstract
Schizophyllan (SPG) is a kind of beta-1,3-glucan which has glucose side chain through a beta-1,6-glycosil bond (Fig. 1). It was found that SPG could form complex with single stranded polynucleotides. SPG forms triple stranded complex with single stranded RNAs thorough hydrogen bonding and hydrophobic interaction. It was found tht polynucleotide was protected from nuclease attacking to form the complex with SPG, and SPG enhanced antisense efficient.
| Original language | English |
|---|---|
| Pages (from-to) | 223-224 |
| Number of pages | 2 |
| Journal | Nucleic acids research. Supplement (2001) |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2001 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
Application of schizophyllan as a novel gene carrier. / Sakurai, K.; Kimura, T.; Koumoto, K.; Mizu, M.; Kobayashi, R.; Shinkai, S.
In: Nucleic acids research. Supplement (2001), No. 1, 2001, p. 223-224.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Application of schizophyllan as a novel gene carrier.
AU - Sakurai, K.
AU - Kimura, T.
AU - Koumoto, K.
AU - Mizu, M.
AU - Kobayashi, R.
AU - Shinkai, S.
PY - 2001
Y1 - 2001
N2 - Schizophyllan (SPG) is a kind of beta-1,3-glucan which has glucose side chain through a beta-1,6-glycosil bond (Fig. 1). It was found that SPG could form complex with single stranded polynucleotides. SPG forms triple stranded complex with single stranded RNAs thorough hydrogen bonding and hydrophobic interaction. It was found tht polynucleotide was protected from nuclease attacking to form the complex with SPG, and SPG enhanced antisense efficient.
AB - Schizophyllan (SPG) is a kind of beta-1,3-glucan which has glucose side chain through a beta-1,6-glycosil bond (Fig. 1). It was found that SPG could form complex with single stranded polynucleotides. SPG forms triple stranded complex with single stranded RNAs thorough hydrogen bonding and hydrophobic interaction. It was found tht polynucleotide was protected from nuclease attacking to form the complex with SPG, and SPG enhanced antisense efficient.
UR - http://www.scopus.com/inward/record.url?scp=0041703239&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0041703239&partnerID=8YFLogxK
U2 - 10.1093/nass/1.1.223
DO - 10.1093/nass/1.1.223
M3 - Article
C2 - 12836345
AN - SCOPUS:0041703239
SP - 223
EP - 224
JO - Nucleic acids research. Supplement (2001)
JF - Nucleic acids research. Supplement (2001)
IS - 1
ER -