Application of schizophyllan as a novel gene carrier.

K. Sakurai, T. Kimura, K. Koumoto, M. Mizu, R. Kobayashi, S. Shinkai

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Schizophyllan (SPG) is a kind of beta-1,3-glucan which has glucose side chain through a beta-1,6-glycosil bond (Fig. 1). It was found that SPG could form complex with single stranded polynucleotides. SPG forms triple stranded complex with single stranded RNAs thorough hydrogen bonding and hydrophobic interaction. It was found tht polynucleotide was protected from nuclease attacking to form the complex with SPG, and SPG enhanced antisense efficient.

Original languageEnglish
Pages (from-to)223-224
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number1
DOIs
Publication statusPublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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  • Cite this

    Sakurai, K., Kimura, T., Koumoto, K., Mizu, M., Kobayashi, R., & Shinkai, S. (2001). Application of schizophyllan as a novel gene carrier. Nucleic acids research. Supplement (2001), (1), 223-224. https://doi.org/10.1093/nass/1.1.223