Application of schizophyllan as a novel gene carrier.

K. Sakurai, T. Kimura, K. Koumoto, M. Mizu, R. Kobayashi, S. Shinkai

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Schizophyllan (SPG) is a kind of beta-1,3-glucan which has glucose side chain through a beta-1,6-glycosil bond (Fig. 1). It was found that SPG could form complex with single stranded polynucleotides. SPG forms triple stranded complex with single stranded RNAs thorough hydrogen bonding and hydrophobic interaction. It was found tht polynucleotide was protected from nuclease attacking to form the complex with SPG, and SPG enhanced antisense efficient.

Original languageEnglish
Pages (from-to)223-224
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number1
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Sizofiran
Polynucleotides
Hydrogen Bonding
Hydrophobic and Hydrophilic Interactions
Genes
RNA
Glucose

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Sakurai, K., Kimura, T., Koumoto, K., Mizu, M., Kobayashi, R., & Shinkai, S. (2001). Application of schizophyllan as a novel gene carrier. Nucleic acids research. Supplement (2001), (1), 223-224. https://doi.org/10.1093/nass/1.1.223

Application of schizophyllan as a novel gene carrier. / Sakurai, K.; Kimura, T.; Koumoto, K.; Mizu, M.; Kobayashi, R.; Shinkai, S.

In: Nucleic acids research. Supplement (2001), No. 1, 2001, p. 223-224.

Research output: Contribution to journalArticle

Sakurai, K, Kimura, T, Koumoto, K, Mizu, M, Kobayashi, R & Shinkai, S 2001, 'Application of schizophyllan as a novel gene carrier.', Nucleic acids research. Supplement (2001), no. 1, pp. 223-224. https://doi.org/10.1093/nass/1.1.223
Sakurai, K. ; Kimura, T. ; Koumoto, K. ; Mizu, M. ; Kobayashi, R. ; Shinkai, S. / Application of schizophyllan as a novel gene carrier. In: Nucleic acids research. Supplement (2001). 2001 ; No. 1. pp. 223-224.
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