Appositional bone formation by OCP-Collagen composite

Y. Suzukfi, S. Kamakura, Y. Honda, Takahisa Anada, K. Hatori, K. Sasaki, O. Suzuki

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Synthetic octacalcium phosphate (OCP) has been shown to enhance bone formation and to biodegrade if implanted into bone defects. Here, we hypothesized that an OCP-atelocollagen complex (OCP/Col) is biodegradable and can induce bone formation in a thickness-dependent manner when implanted into the calvaria. OCP/Col disks (diameter, 9 mm; thickness, 1 or 3 mm) were implanted into a subperiosteal pocket in the calvaria of 12-week-old Wistar rats for 4, 8, and 12 weeks and subsequent bone formation was monitored. X-ray diffraction analysis and Fourier transform infrared spectroscopy showed that OCP in the OCP/Col implants was converted into a carbonate-rich apatite after 4 weeks. Although thinner disks tended to be replaced by new bone, thicker disks were progressively resorbed by osteoclast-like cells until 12 weeks, possibly via the increased mechanical load in the subperiosteal pocket. Therefore, OCP/Col can increase appositional intramembranous bone formation if the appropriate size of the implant is applied.

Original languageEnglish
Pages (from-to)1107-1112
Number of pages6
JournalJournal of Dental Research
Volume88
Issue number12
DOIs
Publication statusPublished - Dec 1 2009
Externally publishedYes

Fingerprint

Osteogenesis
Collagen
Skull
Bone and Bones
Osteoclasts
Fourier Transform Infrared Spectroscopy
X-Ray Diffraction
octacalcium phosphate
Wistar Rats

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Suzukfi, Y., Kamakura, S., Honda, Y., Anada, T., Hatori, K., Sasaki, K., & Suzuki, O. (2009). Appositional bone formation by OCP-Collagen composite. Journal of Dental Research, 88(12), 1107-1112. https://doi.org/10.1177/0022034509351378

Appositional bone formation by OCP-Collagen composite. / Suzukfi, Y.; Kamakura, S.; Honda, Y.; Anada, Takahisa; Hatori, K.; Sasaki, K.; Suzuki, O.

In: Journal of Dental Research, Vol. 88, No. 12, 01.12.2009, p. 1107-1112.

Research output: Contribution to journalArticle

Suzukfi, Y, Kamakura, S, Honda, Y, Anada, T, Hatori, K, Sasaki, K & Suzuki, O 2009, 'Appositional bone formation by OCP-Collagen composite', Journal of Dental Research, vol. 88, no. 12, pp. 1107-1112. https://doi.org/10.1177/0022034509351378
Suzukfi Y, Kamakura S, Honda Y, Anada T, Hatori K, Sasaki K et al. Appositional bone formation by OCP-Collagen composite. Journal of Dental Research. 2009 Dec 1;88(12):1107-1112. https://doi.org/10.1177/0022034509351378
Suzukfi, Y. ; Kamakura, S. ; Honda, Y. ; Anada, Takahisa ; Hatori, K. ; Sasaki, K. ; Suzuki, O. / Appositional bone formation by OCP-Collagen composite. In: Journal of Dental Research. 2009 ; Vol. 88, No. 12. pp. 1107-1112.
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