Approach for the development of new gene therapy method using cell signal transduction

Jeong Hun Kang; Kota Kodama; Jun Oishi; Kenji Kawamura; Takuro Niidome; Yoshiki Katayama

Approach for the development of new gene therapy method using cell signal transduction

Jeong Hun Kang, Kota Kodama, Jun Oishi, Kenji Kawamura, Takuro Niidome, Yoshiki Katayama

Research output: Contribution to conference › Paper › peer-review

Abstract

Protein kinase C (PKC) alpha plays a key role in the differentiation and proliferation of tumor cell. The development of new carrier for the gene therapy and its application to animal were tested. The carrier was made by the synthesis of peptide with high phosphorylation reaction on PKC alpha and polyacrylamide. The anionic DNA was connected with cationic peptides and was released after the phosphorylation reaction with PKC alpha. Higher phosphorylation results from melanoma tissues were obtained, compared with normal subcutaneous tissues, suggesting that the new developed method using the cell signal transduction response to PKC alpha can be applied to tumor treatment.

Original language	English
Number of pages	1
Publication status	Published - Dec 1 2005
Event	54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: May 25 2005 → May 27 2005

Other

Other	54th SPSJ Annual Meeting 2005
Country/Territory	Japan
City	Yokohama
Period	5/25/05 → 5/27/05

All Science Journal Classification (ASJC) codes

Engineering(all)

Cite this

@conference{758f823d658a402fb2277adb5db27903,

title = "Approach for the development of new gene therapy method using cell signal transduction",

abstract = "Protein kinase C (PKC) alpha plays a key role in the differentiation and proliferation of tumor cell. The development of new carrier for the gene therapy and its application to animal were tested. The carrier was made by the synthesis of peptide with high phosphorylation reaction on PKC alpha and polyacrylamide. The anionic DNA was connected with cationic peptides and was released after the phosphorylation reaction with PKC alpha. Higher phosphorylation results from melanoma tissues were obtained, compared with normal subcutaneous tissues, suggesting that the new developed method using the cell signal transduction response to PKC alpha can be applied to tumor treatment.",

author = "Kang, {Jeong Hun} and Kota Kodama and Jun Oishi and Kenji Kawamura and Takuro Niidome and Yoshiki Katayama",

year = "2005",

month = dec,

day = "1",

language = "English",

note = "54th SPSJ Annual Meeting 2005 ; Conference date: 25-05-2005 Through 27-05-2005",

}

TY - CONF

T1 - Approach for the development of new gene therapy method using cell signal transduction

AU - Kang, Jeong Hun

AU - Kodama, Kota

AU - Oishi, Jun

AU - Kawamura, Kenji

AU - Niidome, Takuro

AU - Katayama, Yoshiki

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Protein kinase C (PKC) alpha plays a key role in the differentiation and proliferation of tumor cell. The development of new carrier for the gene therapy and its application to animal were tested. The carrier was made by the synthesis of peptide with high phosphorylation reaction on PKC alpha and polyacrylamide. The anionic DNA was connected with cationic peptides and was released after the phosphorylation reaction with PKC alpha. Higher phosphorylation results from melanoma tissues were obtained, compared with normal subcutaneous tissues, suggesting that the new developed method using the cell signal transduction response to PKC alpha can be applied to tumor treatment.

AB - Protein kinase C (PKC) alpha plays a key role in the differentiation and proliferation of tumor cell. The development of new carrier for the gene therapy and its application to animal were tested. The carrier was made by the synthesis of peptide with high phosphorylation reaction on PKC alpha and polyacrylamide. The anionic DNA was connected with cationic peptides and was released after the phosphorylation reaction with PKC alpha. Higher phosphorylation results from melanoma tissues were obtained, compared with normal subcutaneous tissues, suggesting that the new developed method using the cell signal transduction response to PKC alpha can be applied to tumor treatment.

UR - http://www.scopus.com/inward/record.url?scp=33645643184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645643184&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33645643184

T2 - 54th SPSJ Annual Meeting 2005

Y2 - 25 May 2005 through 27 May 2005

ER -

Approach for the development of new gene therapy method using cell signal transduction

Abstract

Other

All Science Journal Classification (ASJC) codes

Other files and links

Fingerprint

Cite this