Approach for the development of new gene therapy method using cell signal transduction

Jeong Hun Kang, Kota Kodama, Jun Oishi, Kenji Kawamura, Takuro Niidome, Yoshiki Katayama

Research output: Contribution to conferencePaperpeer-review

Abstract

Protein kinase C (PKC) alpha plays a key role in the differentiation and proliferation of tumor cell. The development of new carrier for the gene therapy and its application to animal were tested. The carrier was made by the synthesis of peptide with high phosphorylation reaction on PKC alpha and polyacrylamide. The anionic DNA was connected with cationic peptides and was released after the phosphorylation reaction with PKC alpha. Higher phosphorylation results from melanoma tissues were obtained, compared with normal subcutaneous tissues, suggesting that the new developed method using the cell signal transduction response to PKC alpha can be applied to tumor treatment.

Original languageEnglish
Number of pages1
Publication statusPublished - Dec 1 2005
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: May 25 2005May 27 2005

Other

Other54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period5/25/055/27/05

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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