Approaches to catalytic asymmetric formation and reactions of lithium enolates

Kenji Koga, Mitsuru Shindo

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

Studies have been made to explore the use of chiral chelated lithium amides or their corresponding amines for enantioselective reactions. Some of our results are discussed in terms of enantioselective deprotonation of prochiral cyclic ketones, kinetic resolution of racemic 2-substituted cyclohexanones, regioselective deprotonation of optically active 3-keto steroids, enantioselective alkylation and protonation of achiral lithium enolates. Examples of catalytic asymmetric deprotonation and alkylation by the present strategy are also discussed.

Original languageEnglish
Pages (from-to)1021-1032
Number of pages12
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume53
Issue number11
DOIs
Publication statusPublished - 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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