Are free radical reactions increased in the diabetic eye?

Mayumi Yamato, Shingo Matsumoto, Katsuaki Ura, Ken Ichi Yamada, Tatsuya Naganuma, Toyoshi Inoguchi, Toshiaki Watanabe, Hideo Utsumi

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Reactive oxygen species (ROS) are thought to play a significant role in the development of diabetic retinopathy; however, no direct evidence supports ROS generation in vivo. This study used in vivo electron spin resonance (ESR) spectroscopy with a surface resonator to detect local free radical reactions. The ESR signal decay of carbamoyl-PROXYL was enhanced in the eyes of streptozotocin (STZ)-induced diabetic mice. This enhanced signal decay was suppressed by the administration of SOD or the pretreatment with aminoguanidine. We demonstrate, for the first time, specific free radical reactions in the eyes of mice with STZ-induced diabetes.

Original languageEnglish
Pages (from-to)367-373
Number of pages7
JournalAntioxidants and Redox Signaling
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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