Are microtubules tension sensors?

Olivier Hamant, Daisuke Inoue, David Bouchez, Jacques Dumais, Eric Mjolsness

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Mechanical signals play many roles in cell and developmental biology. Several mechanotransduction pathways have been uncovered, but the mechanisms identified so far only address the perception of stress intensity. Mechanical stresses are tensorial in nature, and thus provide dual mechanical information: stress magnitude and direction. Here we propose a parsimonious mechanism for the perception of the principal stress direction. In vitro experiments show that microtubules are stabilized under tension. Based on these results, we explore the possibility that such microtubule stabilization operates in vivo, most notably in plant cells where turgor-driven tensile stresses exceed greatly those observed in animal cells.

Original languageEnglish
Article number2360
JournalNature communications
Volume10
Issue number1
DOIs
Publication statusPublished - Dec 1 2019

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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    Hamant, O., Inoue, D., Bouchez, D., Dumais, J., & Mjolsness, E. (2019). Are microtubules tension sensors? Nature communications, 10(1), [2360]. https://doi.org/10.1038/s41467-019-10207-y