Arterial spin-labeling in central nervous system infection

Tomoyuki Noguchi, Yusuke Yakushiji, Masashi Nishihara, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Muneaki Matsuo, Shinya Azama, Hiroyuki Irie

Research output: Contribution to journalArticle

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Abstract

Purpose: To investigate the characteristics of arterial spin-labeling magnetic resonance imaging (ASL-MRI) in central nervous system (CNS) infection. Methods: Thirty-two patients with CNS infections underwent a pulsed ASL-MRI. The findings on ASL-MRI were retrospectively assessed for the pathogens as well as each of the following four pathology classified based on conventional MRI findings: non-purulent parenchymal involvement, meningeal involvement, abscess formation, and ventricular involvement. Results: Among the 17 patients with non-purulent parenchymal involvement, ASL-MRI revealed high perfusion in 8 patients (47%) and low perfusion 1 patient (6%). Especially, four of five patients (80%) with definite or suspected herpes simplex virus (HSV) infection showed high perfusion on ASL-MRI. Seventeen of 22 patients (77%) with meningeal involvement showed high perfusion along the cerebral sulci irrespective of the pathogens. Meanwhile, 4 of 16 lesions (25%) with abscess formation showed low perfusion and one of six patients (17%) with ventricular involvement had high perfusion. Conclusions: The characteristics of ASL-MRI in CNS infections were clearly delineated. ASLMRI could be helpful for monitoring the brain function in CNS infections noninvasively.

Original languageEnglish
Pages (from-to)386-394
Number of pages9
JournalMagnetic Resonance in Medical Sciences
Volume15
Issue number4
DOIs
Publication statusPublished - Jan 1 2016

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Central Nervous System Infections
Perfusion
Magnetic Resonance Imaging
Abscess
Virus Diseases
Simplexvirus
Pathology
Brain

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Arterial spin-labeling in central nervous system infection. / Noguchi, Tomoyuki; Yakushiji, Yusuke; Nishihara, Masashi; Togao, Osamu; Yamashita, Koji; Kikuchi, Kazufumi; Matsuo, Muneaki; Azama, Shinya; Irie, Hiroyuki.

In: Magnetic Resonance in Medical Sciences, Vol. 15, No. 4, 01.01.2016, p. 386-394.

Research output: Contribution to journalArticle

Noguchi, T, Yakushiji, Y, Nishihara, M, Togao, O, Yamashita, K, Kikuchi, K, Matsuo, M, Azama, S & Irie, H 2016, 'Arterial spin-labeling in central nervous system infection', Magnetic Resonance in Medical Sciences, vol. 15, no. 4, pp. 386-394. https://doi.org/10.2463/mrms.mp.2015-0140
Noguchi, Tomoyuki ; Yakushiji, Yusuke ; Nishihara, Masashi ; Togao, Osamu ; Yamashita, Koji ; Kikuchi, Kazufumi ; Matsuo, Muneaki ; Azama, Shinya ; Irie, Hiroyuki. / Arterial spin-labeling in central nervous system infection. In: Magnetic Resonance in Medical Sciences. 2016 ; Vol. 15, No. 4. pp. 386-394.
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