TY - JOUR
T1 - Arterial steroid injection therapy can inhibit the progression of severe acute hepatic failure toward fulminant liver failure
AU - Kotoh, Kazuhiro
AU - Enjoji, Munechika
AU - Nakamuta, Makoto
AU - Yoshimoto, Tsuyoshi
AU - Kohjima, Motoyuki
AU - Morizono, Shusuke
AU - Yamashita, Shinsaku
AU - Horikawa, Yuki
AU - Yoshimitsu, Kengo
AU - Tajima, Tsuyoshi
AU - Asayama, Yoshiki
AU - Ishigami, Kousei
AU - Hirakawa, Masakazu
PY - 2006/11/7
Y1 - 2006/11/7
N2 - Aim: To utilize transcatheter arterial steroid injection theraphy (TASIT) via the hepatic artery to reduce hepatic macrophage activity in patients with severe acute hepatic failure. Methods: Thirty-four patients with severe acute hepatic failure were admitted to our hospital between June 2002 to June 2006 providing for the possibility of liver transplantation (LT). Seventeen patients were treated using traditional liver supportive procedures, and the other 17 patients additionally underwent TASIT with 1000 mg methylprednisolone per day for 3 continuous days. Results: Of the 17 patients who received TASIT, 13 were cured without any complications, 2 died, and 2 underwent LT. Of the 17 patients who did not receive TASIT, 4 were self-limiting, 7 died, and 6 underwent LT. Univariate logistic analysis revealed that ascites, serum albumin, prothrombin time, platelet count, and TASIT were significant variables for predicating the prognosis. Multivariate logistic regression analysis using stepwise variable selection showed that prothrombin time, platelet count, and TASIT were independent predictive factors. Conclusion: TASIT might effectively prevent the progression of severe acute hepatic failure to a fatal stage of fulminant liver failure.
AB - Aim: To utilize transcatheter arterial steroid injection theraphy (TASIT) via the hepatic artery to reduce hepatic macrophage activity in patients with severe acute hepatic failure. Methods: Thirty-four patients with severe acute hepatic failure were admitted to our hospital between June 2002 to June 2006 providing for the possibility of liver transplantation (LT). Seventeen patients were treated using traditional liver supportive procedures, and the other 17 patients additionally underwent TASIT with 1000 mg methylprednisolone per day for 3 continuous days. Results: Of the 17 patients who received TASIT, 13 were cured without any complications, 2 died, and 2 underwent LT. Of the 17 patients who did not receive TASIT, 4 were self-limiting, 7 died, and 6 underwent LT. Univariate logistic analysis revealed that ascites, serum albumin, prothrombin time, platelet count, and TASIT were significant variables for predicating the prognosis. Multivariate logistic regression analysis using stepwise variable selection showed that prothrombin time, platelet count, and TASIT were independent predictive factors. Conclusion: TASIT might effectively prevent the progression of severe acute hepatic failure to a fatal stage of fulminant liver failure.
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U2 - 10.3748/wjg.v12.i41.6678
DO - 10.3748/wjg.v12.i41.6678
M3 - Article
C2 - 17075983
AN - SCOPUS:33751298473
VL - 12
SP - 6678
EP - 6682
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 41
ER -