Arthroamide, a Cyclic Depsipeptide with Quorum Sensing Inhibitory Activity from Arthrobacter sp.

Yasuhiro Igarashi; Kazuki Yamamoto; Takao Fukuda; Akane Shojima; Jiro Nakayama; Lorena Carro; Martha E. Trujillo

doi:10.1021/acs.jnatprod.5b00540

Arthroamide, a Cyclic Depsipeptide with Quorum Sensing Inhibitory Activity from Arthrobacter sp.

Yasuhiro Igarashi, Kazuki Yamamoto, Takao Fukuda, Akane Shojima, Jiro Nakayama, Lorena Carro, Martha E. Trujillo

Systems Biology

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Nonfilamentous actinobacteria have been less studied as secondary metabolite producers than their filamentous counterparts such as Streptomyces. From our collection of nonfilamentous actinobacteria isolated from sandstone, an Arthrobacter strain was found to produce a new cyclic peptide arthroamide (1) together with the known compound turnagainolide A (2). These compounds inhibited the quorum sensing signaling of Staphylococcus aureus in the submicromolar to micromolar range.

Original language	English
Pages (from-to)	2827-2831
Number of pages	5
Journal	Journal of Natural Products
Volume	78
Issue number	11
DOIs	https://doi.org/10.1021/acs.jnatprod.5b00540
Publication status	Published - Nov 25 2015

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/acs.jnatprod.5b00540

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title = "Arthroamide, a Cyclic Depsipeptide with Quorum Sensing Inhibitory Activity from Arthrobacter sp.",

abstract = "Nonfilamentous actinobacteria have been less studied as secondary metabolite producers than their filamentous counterparts such as Streptomyces. From our collection of nonfilamentous actinobacteria isolated from sandstone, an Arthrobacter strain was found to produce a new cyclic peptide arthroamide (1) together with the known compound turnagainolide A (2). These compounds inhibited the quorum sensing signaling of Staphylococcus aureus in the submicromolar to micromolar range.",

author = "Yasuhiro Igarashi and Kazuki Yamamoto and Takao Fukuda and Akane Shojima and Jiro Nakayama and Lorena Carro and Trujillo, {Martha E.}",

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AU - Igarashi, Yasuhiro

AU - Yamamoto, Kazuki

AU - Fukuda, Takao

AU - Shojima, Akane

AU - Nakayama, Jiro

AU - Carro, Lorena

AU - Trujillo, Martha E.

PY - 2015/11/25

Y1 - 2015/11/25

N2 - Nonfilamentous actinobacteria have been less studied as secondary metabolite producers than their filamentous counterparts such as Streptomyces. From our collection of nonfilamentous actinobacteria isolated from sandstone, an Arthrobacter strain was found to produce a new cyclic peptide arthroamide (1) together with the known compound turnagainolide A (2). These compounds inhibited the quorum sensing signaling of Staphylococcus aureus in the submicromolar to micromolar range.

AB - Nonfilamentous actinobacteria have been less studied as secondary metabolite producers than their filamentous counterparts such as Streptomyces. From our collection of nonfilamentous actinobacteria isolated from sandstone, an Arthrobacter strain was found to produce a new cyclic peptide arthroamide (1) together with the known compound turnagainolide A (2). These compounds inhibited the quorum sensing signaling of Staphylococcus aureus in the submicromolar to micromolar range.

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JF - Journal of Natural Products

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ER -

Arthroamide, a Cyclic Depsipeptide with Quorum Sensing Inhibitory Activity from Arthrobacter sp.

Abstract

All Science Journal Classification (ASJC) codes

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