Arthroamide, a Cyclic Depsipeptide with Quorum Sensing Inhibitory Activity from Arthrobacter sp.

Yasuhiro Igarashi, Kazuki Yamamoto, Takao Fukuda, Akane Shojima, Jiro Nakayama, Lorena Carro, Martha E. Trujillo

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Nonfilamentous actinobacteria have been less studied as secondary metabolite producers than their filamentous counterparts such as Streptomyces. From our collection of nonfilamentous actinobacteria isolated from sandstone, an Arthrobacter strain was found to produce a new cyclic peptide arthroamide (1) together with the known compound turnagainolide A (2). These compounds inhibited the quorum sensing signaling of Staphylococcus aureus in the submicromolar to micromolar range.

Original languageEnglish
Pages (from-to)2827-2831
Number of pages5
JournalJournal of Natural Products
Volume78
Issue number11
DOIs
Publication statusPublished - Nov 25 2015

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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