TY - GEN
T1 - Artificial baroreflex system restores volume tolerance in the absence of native baroreflex
AU - Hosokawa, Kazuya
AU - Funakoshi, Kouta
AU - Tanaka, Atsushi
AU - Sakamoto, Takafumi
AU - Onitsuka, Ken
AU - Sakamoto, Kazuo
AU - Tobushi, Tomoyuki
AU - Fujino, Takeo
AU - Saku, Keita
AU - Murayama, Yoshinori
AU - Ide, Tomomi
AU - Sunagawa, Kenji
PY - 2011
Y1 - 2011
N2 - The arterial baroreflex stabilizes arterial pressure by modulating the mechanical properties of cardiovascular system. We previously demonstrated that the baroreflex impairment makes the circulatory system extremely sensitive to volume overload and predisposes to pulmonary edema irrespective of left ventricular systolic function. To overcome the volume intolerance, we developed an artificial baroreflex system by directly stimulating the carotid sinus nerves in response to changes in arterial pressure. The artificial baroreflex system precisely reproduced the native arterial pressure response and restored physiological volume buffering function. We conclude that the artificial baroreflex system would be an attractive tool in preventing pulmonary edema in patients with impaired baroreflex function.
AB - The arterial baroreflex stabilizes arterial pressure by modulating the mechanical properties of cardiovascular system. We previously demonstrated that the baroreflex impairment makes the circulatory system extremely sensitive to volume overload and predisposes to pulmonary edema irrespective of left ventricular systolic function. To overcome the volume intolerance, we developed an artificial baroreflex system by directly stimulating the carotid sinus nerves in response to changes in arterial pressure. The artificial baroreflex system precisely reproduced the native arterial pressure response and restored physiological volume buffering function. We conclude that the artificial baroreflex system would be an attractive tool in preventing pulmonary edema in patients with impaired baroreflex function.
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U2 - 10.1109/IEMBS.2011.6090157
DO - 10.1109/IEMBS.2011.6090157
M3 - Conference contribution
C2 - 22254405
AN - SCOPUS:84861934694
SN - 9781424441211
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 697
EP - 699
BT - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
T2 - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Y2 - 30 August 2011 through 3 September 2011
ER -