Artificial baroreflex system restores volume tolerance in the absence of native baroreflex

Kazuya Hosokawa; Kouta Funakoshi; Atsushi Tanaka; takafumi sakamoto; Ken Onitsuka; Kazuo Sakamoto; Tomoyuki Tobushi; Takeo Fujino; Keita Saku; Yoshinori Murayama; Tomomi Ide; Kenji Sunagawa

doi:10.1109/IEMBS.2011.6090157

Artificial baroreflex system restores volume tolerance in the absence of native baroreflex

Kazuya Hosokawa, Kouta Funakoshi, Atsushi Tanaka, takafumi sakamoto, Ken Onitsuka, Kazuo Sakamoto, Tomoyuki Tobushi, Takeo Fujino, Keita Saku, Yoshinori Murayama, Tomomi Ide, Kenji Sunagawa

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Citations (Scopus)

Abstract

The arterial baroreflex stabilizes arterial pressure by modulating the mechanical properties of cardiovascular system. We previously demonstrated that the baroreflex impairment makes the circulatory system extremely sensitive to volume overload and predisposes to pulmonary edema irrespective of left ventricular systolic function. To overcome the volume intolerance, we developed an artificial baroreflex system by directly stimulating the carotid sinus nerves in response to changes in arterial pressure. The artificial baroreflex system precisely reproduced the native arterial pressure response and restored physiological volume buffering function. We conclude that the artificial baroreflex system would be an attractive tool in preventing pulmonary edema in patients with impaired baroreflex function.

Original language	English
Title of host publication	33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Pages	697-699
Number of pages	3
DOIs	https://doi.org/10.1109/IEMBS.2011.6090157
Publication status	Published - Dec 26 2011
Event	33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 - Boston, MA, United States Duration: Aug 30 2011 → Sep 3 2011

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)	1557-170X

Other

Other	33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Country	United States
City	Boston, MA
Period	8/30/11 → 9/3/11

All Science Journal Classification (ASJC) codes

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

Access to Document

10.1109/IEMBS.2011.6090157

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Hosokawa, K., Funakoshi, K., Tanaka, A., sakamoto, T., Onitsuka, K., Sakamoto, K., Tobushi, T., Fujino, T., Saku, K., Murayama, Y., Ide, T., & Sunagawa, K. (2011). Artificial baroreflex system restores volume tolerance in the absence of native baroreflex. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 (pp. 697-699). [6090157] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/IEMBS.2011.6090157

Artificial baroreflex system restores volume tolerance in the absence of native baroreflex. / Hosokawa, Kazuya; Funakoshi, Kouta; Tanaka, Atsushi; sakamoto, takafumi; Onitsuka, Ken; Sakamoto, Kazuo; Tobushi, Tomoyuki; Fujino, Takeo; Saku, Keita; Murayama, Yoshinori; Ide, Tomomi; Sunagawa, Kenji.

33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. p. 697-699 6090157 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Hosokawa, K, Funakoshi, K, Tanaka, A, sakamoto, T, Onitsuka, K, Sakamoto, K, Tobushi, T, Fujino, T, Saku, K, Murayama, Y, Ide, T & Sunagawa, K 2011, Artificial baroreflex system restores volume tolerance in the absence of native baroreflex. in 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011., 6090157, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 697-699, 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011, Boston, MA, United States, 8/30/11. https://doi.org/10.1109/IEMBS.2011.6090157

Hosokawa K, Funakoshi K, Tanaka A, sakamoto T, Onitsuka K, Sakamoto K et al. Artificial baroreflex system restores volume tolerance in the absence of native baroreflex. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. p. 697-699. 6090157. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/IEMBS.2011.6090157

Hosokawa, Kazuya ; Funakoshi, Kouta ; Tanaka, Atsushi ; sakamoto, takafumi ; Onitsuka, Ken ; Sakamoto, Kazuo ; Tobushi, Tomoyuki ; Fujino, Takeo ; Saku, Keita ; Murayama, Yoshinori ; Ide, Tomomi ; Sunagawa, Kenji. / Artificial baroreflex system restores volume tolerance in the absence of native baroreflex. 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. pp. 697-699 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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abstract = "The arterial baroreflex stabilizes arterial pressure by modulating the mechanical properties of cardiovascular system. We previously demonstrated that the baroreflex impairment makes the circulatory system extremely sensitive to volume overload and predisposes to pulmonary edema irrespective of left ventricular systolic function. To overcome the volume intolerance, we developed an artificial baroreflex system by directly stimulating the carotid sinus nerves in response to changes in arterial pressure. The artificial baroreflex system precisely reproduced the native arterial pressure response and restored physiological volume buffering function. We conclude that the artificial baroreflex system would be an attractive tool in preventing pulmonary edema in patients with impaired baroreflex function.",

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