Artificial gene regulation system responding to HIV infection

Kota Kodam; Yoko Shojii; Hideki Nakashima; Jeong Hun Kang; Kenji Kawamura; Jun Oishi; Takuro Niidome; Yoshiki Katayama

Artificial gene regulation system responding to HIV infection

Kota Kodam, Yoko Shojii, Hideki Nakashima, Jeong Hun Kang, Kenji Kawamura, Jun Oishi, Takuro Niidome, Yoshiki Katayama

Materials Science and Engineering, School of Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

We describe here a new peptide-polymer conjugate that can activate gene expression responding to HIV protease. This polymer formed tight complex with DNA and could deliver the DNA into living cell efficiently due to the existence of Tat peptide sequence. In this complex, the gene expression was totally suppressed. However, if the complex is delivered into HIV infectious cell, the complex is disintegrated to release DNA to activate gene expression. Thus, the conjugate realize the HIV infectious cell-specific gene expression of transgene. This concept will provide a new methodology for cell-specific gene therapy for virus infectious diseases.

Original language	English
Number of pages	1
Publication status	Published - Dec 1 2005
Event	54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: May 25 2005 → May 27 2005

Other

Other	54th SPSJ Annual Meeting 2005
Country	Japan
City	Yokohama
Period	5/25/05 → 5/27/05

All Science Journal Classification (ASJC) codes

Engineering(all)

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title = "Artificial gene regulation system responding to HIV infection",

abstract = "We describe here a new peptide-polymer conjugate that can activate gene expression responding to HIV protease. This polymer formed tight complex with DNA and could deliver the DNA into living cell efficiently due to the existence of Tat peptide sequence. In this complex, the gene expression was totally suppressed. However, if the complex is delivered into HIV infectious cell, the complex is disintegrated to release DNA to activate gene expression. Thus, the conjugate realize the HIV infectious cell-specific gene expression of transgene. This concept will provide a new methodology for cell-specific gene therapy for virus infectious diseases.",

author = "Kota Kodam and Yoko Shojii and Hideki Nakashima and Kang, {Jeong Hun} and Kenji Kawamura and Jun Oishi and Takuro Niidome and Yoshiki Katayama",

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T1 - Artificial gene regulation system responding to HIV infection

AU - Kodam, Kota

AU - Shojii, Yoko

AU - Nakashima, Hideki

AU - Kang, Jeong Hun

AU - Kawamura, Kenji

AU - Oishi, Jun

AU - Niidome, Takuro

AU - Katayama, Yoshiki

PY - 2005/12/1

Y1 - 2005/12/1

N2 - We describe here a new peptide-polymer conjugate that can activate gene expression responding to HIV protease. This polymer formed tight complex with DNA and could deliver the DNA into living cell efficiently due to the existence of Tat peptide sequence. In this complex, the gene expression was totally suppressed. However, if the complex is delivered into HIV infectious cell, the complex is disintegrated to release DNA to activate gene expression. Thus, the conjugate realize the HIV infectious cell-specific gene expression of transgene. This concept will provide a new methodology for cell-specific gene therapy for virus infectious diseases.

AB - We describe here a new peptide-polymer conjugate that can activate gene expression responding to HIV protease. This polymer formed tight complex with DNA and could deliver the DNA into living cell efficiently due to the existence of Tat peptide sequence. In this complex, the gene expression was totally suppressed. However, if the complex is delivered into HIV infectious cell, the complex is disintegrated to release DNA to activate gene expression. Thus, the conjugate realize the HIV infectious cell-specific gene expression of transgene. This concept will provide a new methodology for cell-specific gene therapy for virus infectious diseases.

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T2 - 54th SPSJ Annual Meeting 2005

Y2 - 25 May 2005 through 27 May 2005

ER -