We describe here a new peptide-polymer conjugate that can activate gene expression responding to HIV protease. This polymer formed tight complex with DNA and could deliver the DNA into living cell efficiently due to the existence of Tat peptide sequence. In this complex, the gene expression was totally suppressed. However, if the complex is delivered into HIV infectious cell, the complex is disintegrated to release DNA to activate gene expression. Thus, the conjugate realize the HIV infectious cell-specific gene expression of transgene. This concept will provide a new methodology for cell-specific gene therapy for virus infectious diseases.
|Number of pages||1|
|Publication status||Published - Dec 1 2005|
|Event||54th SPSJ Annual Meeting 2005 - Yokohama, Japan|
Duration: May 25 2005 → May 27 2005
|Other||54th SPSJ Annual Meeting 2005|
|Period||5/25/05 → 5/27/05|
All Science Journal Classification (ASJC) codes