Artificial gene regulation system responding to HIV infection

Kota Kodam, Yoko Shojii, Hideki Nakashima, Jeong Hun Kang, Kenji Kawamura, Jun Oishi, Takuro Niidome, Yoshiki Katayama

    Research output: Contribution to conferencePaperpeer-review

    Abstract

    We describe here a new peptide-polymer conjugate that can activate gene expression responding to HIV protease. This polymer formed tight complex with DNA and could deliver the DNA into living cell efficiently due to the existence of Tat peptide sequence. In this complex, the gene expression was totally suppressed. However, if the complex is delivered into HIV infectious cell, the complex is disintegrated to release DNA to activate gene expression. Thus, the conjugate realize the HIV infectious cell-specific gene expression of transgene. This concept will provide a new methodology for cell-specific gene therapy for virus infectious diseases.

    Original languageEnglish
    Number of pages1
    Publication statusPublished - Dec 1 2005
    Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
    Duration: May 25 2005May 27 2005

    Other

    Other54th SPSJ Annual Meeting 2005
    Country/TerritoryJapan
    CityYokohama
    Period5/25/055/27/05

    All Science Journal Classification (ASJC) codes

    • Engineering(all)

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