Artificial gene regulation system responding to HIV infection

Kota Kodam, Yoko Shojii, Hideki Nakashima, Jeong Hun Kang, Kenji Kawamura, Jun Oishi, Takuro Niidome, Yoshiki Katayama

Research output: Contribution to conferencePaperpeer-review

Abstract

We describe here a new peptide-polymer conjugate that can activate gene expression responding to HIV protease. This polymer formed tight complex with DNA and could deliver the DNA into living cell efficiently due to the existence of Tat peptide sequence. In this complex, the gene expression was totally suppressed. However, if the complex is delivered into HIV infectious cell, the complex is disintegrated to release DNA to activate gene expression. Thus, the conjugate realize the HIV infectious cell-specific gene expression of transgene. This concept will provide a new methodology for cell-specific gene therapy for virus infectious diseases.

Original languageEnglish
Number of pages1
Publication statusPublished - Dec 1 2005
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: May 25 2005May 27 2005

Other

Other54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period5/25/055/27/05

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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