Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca 2+ influx in rat glioma C6 cells

Tohru Oishi, Keiichi Konoki, Rie Tamate, Kohei Torikai, Futoshi Hasegawa, Nobuaki Matsumori, Michio Murata

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Maitotoxin (MTX) is a ladder-shaped polyether produced by the epiphytic dinoflagellate Gambierdiscus toxicus. It is known to elicit potent toxicity against mammals and induce influx of Ca2+ into cells. An artificial ladder-shaped polyether possessing a 6/7/6/6/7/6/6 heptacyclic ring system, which was designed for elucidating interactions with transmembrane proteins, was found to be the most potent inhibitor against MTX-induced Ca2+ influx that has ever been reported.

Original languageEnglish
Pages (from-to)3619-3622
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number11
DOIs
Publication statusPublished - Jun 1 2012

Fingerprint

Dinoflagellida
Polyethers
Ladders
Glioma
Rats
Mammals
Toxicity
Proteins
maitotoxin

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca 2+ influx in rat glioma C6 cells. / Oishi, Tohru; Konoki, Keiichi; Tamate, Rie; Torikai, Kohei; Hasegawa, Futoshi; Matsumori, Nobuaki; Murata, Michio.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 22, No. 11, 01.06.2012, p. 3619-3622.

Research output: Contribution to journalArticle

@article{4de46c2b86a54f78834f1982dcf61aa6,
title = "Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca 2+ influx in rat glioma C6 cells",
abstract = "Maitotoxin (MTX) is a ladder-shaped polyether produced by the epiphytic dinoflagellate Gambierdiscus toxicus. It is known to elicit potent toxicity against mammals and induce influx of Ca2+ into cells. An artificial ladder-shaped polyether possessing a 6/7/6/6/7/6/6 heptacyclic ring system, which was designed for elucidating interactions with transmembrane proteins, was found to be the most potent inhibitor against MTX-induced Ca2+ influx that has ever been reported.",
author = "Tohru Oishi and Keiichi Konoki and Rie Tamate and Kohei Torikai and Futoshi Hasegawa and Nobuaki Matsumori and Michio Murata",
year = "2012",
month = "6",
day = "1",
doi = "10.1016/j.bmcl.2012.04.053",
language = "English",
volume = "22",
pages = "3619--3622",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca 2+ influx in rat glioma C6 cells

AU - Oishi, Tohru

AU - Konoki, Keiichi

AU - Tamate, Rie

AU - Torikai, Kohei

AU - Hasegawa, Futoshi

AU - Matsumori, Nobuaki

AU - Murata, Michio

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Maitotoxin (MTX) is a ladder-shaped polyether produced by the epiphytic dinoflagellate Gambierdiscus toxicus. It is known to elicit potent toxicity against mammals and induce influx of Ca2+ into cells. An artificial ladder-shaped polyether possessing a 6/7/6/6/7/6/6 heptacyclic ring system, which was designed for elucidating interactions with transmembrane proteins, was found to be the most potent inhibitor against MTX-induced Ca2+ influx that has ever been reported.

AB - Maitotoxin (MTX) is a ladder-shaped polyether produced by the epiphytic dinoflagellate Gambierdiscus toxicus. It is known to elicit potent toxicity against mammals and induce influx of Ca2+ into cells. An artificial ladder-shaped polyether possessing a 6/7/6/6/7/6/6 heptacyclic ring system, which was designed for elucidating interactions with transmembrane proteins, was found to be the most potent inhibitor against MTX-induced Ca2+ influx that has ever been reported.

UR - http://www.scopus.com/inward/record.url?scp=84861185478&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861185478&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2012.04.053

DO - 10.1016/j.bmcl.2012.04.053

M3 - Article

C2 - 22560474

AN - SCOPUS:84861185478

VL - 22

SP - 3619

EP - 3622

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 11

ER -