Artificial peptide-nanospheres self-assembled from three-way junctions of β-sheet-forming peptides

Kazunori Matsuura, Kazuya Murasato, Nobuo Kimizuka

    Research output: Contribution to journalArticlepeer-review

    127 Citations (Scopus)

    Abstract

    Rational design of self-assembly of proteins, which plays pivotal roles in biology, is an important subject for biotechnology and also bottom-up nanotechnology. This paper has proposed a novel strategy for construction of artificial peptide-nanospheres by self-assembly. Mimicking formation of spherical viruses and clathrin, we designed a novel C3-symmetric peptide conjugate bearing three β-sheet-forming peptides. These peptide conjugates formed antiparallel β-structures and self-assembled into nanospheres with the size of about 20 nm in the acidic solution.

    Original languageEnglish
    Pages (from-to)10148-10149
    Number of pages2
    JournalJournal of the American Chemical Society
    Volume127
    Issue number29
    DOIs
    Publication statusPublished - Jul 27 2005

    All Science Journal Classification (ASJC) codes

    • Catalysis
    • Chemistry(all)
    • Biochemistry
    • Colloid and Surface Chemistry

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