TY - JOUR
T1 - Aryl hydrocarbon receptor and dioxin-related health hazards—lessons from yusho
AU - Furue, Masutaka
AU - Ishii, Yuji
AU - Tsukimori, Kiyomi
AU - Tsuji, Gaku
N1 - Funding Information:
Funding: This work was supported by a grant from the Ministry of Health, Labour and Welfare of Japan (H30-Shokuhin-Shitei-005) and a Grant-in-Aid for Scientific Research (C, FAG0K08692) from the Ministry of Education, Culture, Sports, Science and Technology in 2020.
Funding Information:
Acknowledgments: The first author M.F. was the Chief of the Yusho study group, which is supported by the Ministry of Health, Labour and Welfare of Japan, from April 2001 to March 2020. G.T. has served as the Chief of the Yusho study group since April 2020. This review article was drafted as a summary of research at the time of the retirement of M.F. We deeply thank all of the medical, paramedical, laboratory, and administrative staff at the Research and Clinical Center for Yusho and Dioxin and the Yusho study group. We would also like to express our sincere gratitude to coworkers at the Department of Dermatology, Kyushu University and other laboratories for providing numerous opportunities to conduct cooperative research. Finally, we appreciate the warm and enthusiastic supports of patients with Yusho in the conduct of clinical trials and various studies.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/1/2
Y1 - 2021/1/2
N2 - Poisoning by high concentrations of dioxin and its related compounds manifests variable toxic symptoms such as general malaise, chloracne, hyperpigmentation, sputum and cough, pares-thesia or numbness of the extremities, hypertriglyceridemia, perinatal abnormalities, and elevated risks of cancer-related mortality. Such health hazards are observed in patients with Yusho (oil disease in Japanese) who had consumed rice bran oil highly contaminated with 2,3,4,7,8-pentachlo-rodibenzofuran, polychlorinated biphenyls, and polychlorinated quaterphenyls in 1968. The blood concentrations of these congeners in patients with Yusho remain extremely elevated 50 years after onset. Dioxins exert their toxicity via aryl hydrocarbon receptor (AHR) through the generation of reactive oxygen species (ROS). In this review article, we discuss the pathogenic implication of AHR in dioxin-induced health hazards. We also mention the potential therapeutic use of herbal drugs targeting AHR and ROS in patients with Yusho.
AB - Poisoning by high concentrations of dioxin and its related compounds manifests variable toxic symptoms such as general malaise, chloracne, hyperpigmentation, sputum and cough, pares-thesia or numbness of the extremities, hypertriglyceridemia, perinatal abnormalities, and elevated risks of cancer-related mortality. Such health hazards are observed in patients with Yusho (oil disease in Japanese) who had consumed rice bran oil highly contaminated with 2,3,4,7,8-pentachlo-rodibenzofuran, polychlorinated biphenyls, and polychlorinated quaterphenyls in 1968. The blood concentrations of these congeners in patients with Yusho remain extremely elevated 50 years after onset. Dioxins exert their toxicity via aryl hydrocarbon receptor (AHR) through the generation of reactive oxygen species (ROS). In this review article, we discuss the pathogenic implication of AHR in dioxin-induced health hazards. We also mention the potential therapeutic use of herbal drugs targeting AHR and ROS in patients with Yusho.
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U2 - 10.3390/ijms22020708
DO - 10.3390/ijms22020708
M3 - Review article
C2 - 33445793
AN - SCOPUS:85099414074
SN - 1661-6596
VL - 22
SP - 1
EP - 25
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 2
M1 - 708
ER -
