Aryl hydrocarbon receptor in atopic dermatitis and psoriasis

Masutaka Furue, Akiko Hashimoto-Hachiya, Gaku Tsuji

Research output: Contribution to journalReview article

Abstract

The aryl hydrocarbon receptor (AHR)/AHR-nuclear translocator (ARNT) system is a sensitive sensor for small molecular, xenobiotic chemicals of exogenous and endogenous origin, including dioxins, phytochemicals, microbial bioproducts, and tryptophan photoproducts. AHR/ARNT are abundantly expressed in the skin. Once activated, the AHR/ARNT axis strengthens skin barrier functions and accelerates epidermal terminal differentiation by upregulating filaggrin expression. In addition, AHR activation induces oxidative stress. However, some AHR ligands simultaneously activate the nuclear factor-erythroid 2-related factor-2 (NRF2) transcription factor, which is a master switch of antioxidative enzymes that neutralizes oxidative stress. The immunoregulatory system governing T-helper 17/22 (Th17/22) and T regulatory cells (Treg) is also regulated by the AHR system. Notably, AHR agonists, such as tapinarof, are currently used as therapeutic agents in psoriasis and atopic dermatitis. In this review, we summarize recent topics on AHR related to atopic dermatitis and psoriasis.

Original languageEnglish
Article number5424
JournalInternational journal of molecular sciences
Volume20
Issue number21
DOIs
Publication statusPublished - Nov 1 2019

Fingerprint

dermatitis
Aryl Hydrocarbon Receptors
Atopic Dermatitis
Psoriasis
Aryl Hydrocarbon Receptor Nuclear Translocator
hydrocarbons
Hydrocarbons
Oxidative stress
Oxidative Stress
Skin
Dioxins
Phytochemicals
Xenobiotics
Regulatory T-Lymphocytes
Tryptophan
Transcription factors
Transcription Factors
tryptophan
Ligands
enzymes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Aryl hydrocarbon receptor in atopic dermatitis and psoriasis. / Furue, Masutaka; Hashimoto-Hachiya, Akiko; Tsuji, Gaku.

In: International journal of molecular sciences, Vol. 20, No. 21, 5424, 01.11.2019.

Research output: Contribution to journalReview article

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