Asparagus racemosus root extract induced procollagen i expression and inhibited matrix metalloproteinase-1 (MMP-1) in UVB treated human dermal fibroblasts

Asparagus racemosus Willd., known as Shatavari (Rak-Sam-Sib in the Thai language), has been used in traditional medicine and as a food supplement for females with hormone related health conditions due to its estrogenic effects. In cosmetic use, a clinical study in adult volunteers showed an efficacy in delayed wrinkle formation with topical application. In this study, we focused on the effect of A. racemosus root extract on the expression of type I procollagen and matrix metalloproteinase-1 (MMP-1) in ultraviolet B (UVB) treated human dermal fibroblasts. The saponin enriched extract of A. racemosus root was shown to promote type I procollagen synthesis in non-UVB-exposed cells and prevent a decrease in type I procollagen secretion in UVB exposed cells. Moreover, the enhanced MMP-1 expression upon UVB irradiation was suppressed by A. racemosus root extract. These results suggested A. racemosus root extract could be a potential agent as an anti-photoaging ingredient in cosmeceuticals.