Aspirin toxicity in chicks given diets deficient in linoleic acid

Atsushi Murai, Mitsuhiro Furuse, Jun Ichi Okumura

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Abstract

The toxicity of dietary aspirin on growth rate and lipid metabolism was investigated under linoleic acid (LA;18: 2-6) deficient conditions. One-week-old chicks were given diets containing 0 or 2% LA with or without 0.4% aspirin, until 4 weeks of age. Growth was severely depressed by dietary aspirin when chicks were given the LA-free diet. The liver was enlarged by both the aspirin and LA deficiency. The aspirin treatment induced a significant increase of 18:0 and arachidonic acid (20:4n-6) and a decrease of 18:1n-9 in the liver. In chicks fed LA-free diets, the ratio of 20: 3n-9 20:4n-6, which was used as an indicator of LA deficiency, was suppressed by aspirin treatment. In conclusion, the present results suggest that aspirin toxicity is altered by dietary LA concentrations.

Original languageEnglish
Pages (from-to)1047-1051
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume48
Issue number4
DOIs
Publication statusPublished - Jan 1 1994
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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