Assembling Living Building Blocks to Engineer Complex Tissues

Liliang Ouyang, James P.K. Armstrong, Manuel Salmeron-Sanchez, Molly M. Stevens

Research output: Contribution to journalArticle

Abstract

The great demand for tissue and organ grafts, compounded by an aging demographic and a shortage of available donors, has driven the development of bioengineering approaches that can generate biomimetic tissues in vitro. Despite the considerable progress in conventional scaffold-based tissue engineering, the recreation of physiological complexity has remained a challenge. Bottom-up tissue engineering strategies have opened up a new avenue for the modular assembly of living building blocks into customized tissue architectures. This Progress Report overviews the recent progress and trends in the fabrication and assembly of living building blocks, with a key highlight on emerging bioprinting technologies that can be used for modular assembly and complexity in tissue engineering. By summarizing the work to date, providing new classifications of different living building blocks, highlighting state-of-the-art research and trends, and offering personal perspectives on future opportunities, this Progress Report aims to aid and inspire other researchers working in the field of modular tissue engineering.

Original languageEnglish
Article number1909009
JournalAdvanced Functional Materials
DOIs
Publication statusAccepted/In press - Jan 1 2020
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Ouyang, L., Armstrong, J. P. K., Salmeron-Sanchez, M., & Stevens, M. M. (Accepted/In press). Assembling Living Building Blocks to Engineer Complex Tissues. Advanced Functional Materials, [1909009]. https://doi.org/10.1002/adfm.201909009