TY - JOUR
T1 - Assessment of clinical signs associated with adenoviral epidemic keratoconjunctivitis cases in southern Japan between 2011 and 2014
AU - Aoki, Koki
AU - Gonzalez, Gabriel
AU - Hinokuma, Rikutaro
AU - Yawata, Nobuyo
AU - Tsutsumi, Masayuki
AU - Ohno, Shigeaki
AU - Kitaichi, Nobuyoshi
N1 - Funding Information:
We thank Michael Carr (NVRL, University College Dublin and GI-CoRE, Hokkaido University) for comments and suggestions that greatly improved the manuscript.
Publisher Copyright:
© 2019
PY - 2019/12
Y1 - 2019/12
N2 - Adenoviral epidemic keratoconjunctivitis (EKC) is a major cause of ocular morbidity worldwide and specific antiviral therapies are not available. EKC is primarily caused by Human adenovirus D (HAdV-D) types 8, 37, 53, 54, 56 and 64. Considering the genomic variation in HAdV-D, we hypothesized that clinical signs could be differentiated by virus type. The hypothesis was retrospectively tested with clinical signs recorded from 250 patients with ocular infections visiting an ophthalmological clinic in southern Japan between 2011 and 2014. The results showed that conjunctival opacity, corneal epithelial disorders and pre-auricular lymphadenopathy, were more frequently associated with EKC than other ocular infections. Furthermore, HAdV types 8, 37 and 54, caused corneal complications and longer infections significantly more frequently than infections by types 53 and 56 (P < 0.05). Our descriptive results supported that symptoms severity vary with the infecting type, however, further research is needed to improve diagnosis of EKC.
AB - Adenoviral epidemic keratoconjunctivitis (EKC) is a major cause of ocular morbidity worldwide and specific antiviral therapies are not available. EKC is primarily caused by Human adenovirus D (HAdV-D) types 8, 37, 53, 54, 56 and 64. Considering the genomic variation in HAdV-D, we hypothesized that clinical signs could be differentiated by virus type. The hypothesis was retrospectively tested with clinical signs recorded from 250 patients with ocular infections visiting an ophthalmological clinic in southern Japan between 2011 and 2014. The results showed that conjunctival opacity, corneal epithelial disorders and pre-auricular lymphadenopathy, were more frequently associated with EKC than other ocular infections. Furthermore, HAdV types 8, 37 and 54, caused corneal complications and longer infections significantly more frequently than infections by types 53 and 56 (P < 0.05). Our descriptive results supported that symptoms severity vary with the infecting type, however, further research is needed to improve diagnosis of EKC.
UR - http://www.scopus.com/inward/record.url?scp=85073066975&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073066975&partnerID=8YFLogxK
U2 - 10.1016/j.diagmicrobio.2019.114885
DO - 10.1016/j.diagmicrobio.2019.114885
M3 - Article
C2 - 31607514
AN - SCOPUS:85073066975
VL - 95
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
SN - 0732-8893
IS - 4
M1 - 114885
ER -
