Assessment of clinical signs associated with adenoviral epidemic keratoconjunctivitis cases in southern Japan between 2011 and 2014

Koki Aoki, Gabriel Gonzalez, Rikutaro Hinokuma, Nobuyo Yawata, Masayuki Tsutsumi, Shigeaki Ohno, Nobuyoshi Kitaichi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Adenoviral epidemic keratoconjunctivitis (EKC) is a major cause of ocular morbidity worldwide and specific antiviral therapies are not available. EKC is primarily caused by Human adenovirus D (HAdV-D) types 8, 37, 53, 54, 56 and 64. Considering the genomic variation in HAdV-D, we hypothesized that clinical signs could be differentiated by virus type. The hypothesis was retrospectively tested with clinical signs recorded from 250 patients with ocular infections visiting an ophthalmological clinic in southern Japan between 2011 and 2014. The results showed that conjunctival opacity, corneal epithelial disorders and pre-auricular lymphadenopathy, were more frequently associated with EKC than other ocular infections. Furthermore, HAdV types 8, 37 and 54, caused corneal complications and longer infections significantly more frequently than infections by types 53 and 56 (P < 0.05). Our descriptive results supported that symptoms severity vary with the infecting type, however, further research is needed to improve diagnosis of EKC.

Original languageEnglish
Article number114885
JournalDiagnostic Microbiology and Infectious Disease
Volume95
Issue number4
DOIs
Publication statusPublished - Dec 2019

Fingerprint

Keratoconjunctivitis
Japan
Eye Infections
Human Adenoviruses
Corneal Opacity
Infection
Antiviral Agents
Viruses
Morbidity
Research

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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Assessment of clinical signs associated with adenoviral epidemic keratoconjunctivitis cases in southern Japan between 2011 and 2014. / Aoki, Koki; Gonzalez, Gabriel; Hinokuma, Rikutaro; Yawata, Nobuyo; Tsutsumi, Masayuki; Ohno, Shigeaki; Kitaichi, Nobuyoshi.

In: Diagnostic Microbiology and Infectious Disease, Vol. 95, No. 4, 114885, 12.2019.

Research output: Contribution to journalArticle

Aoki, Koki ; Gonzalez, Gabriel ; Hinokuma, Rikutaro ; Yawata, Nobuyo ; Tsutsumi, Masayuki ; Ohno, Shigeaki ; Kitaichi, Nobuyoshi. / Assessment of clinical signs associated with adenoviral epidemic keratoconjunctivitis cases in southern Japan between 2011 and 2014. In: Diagnostic Microbiology and Infectious Disease. 2019 ; Vol. 95, No. 4.
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