Assessment of radiation mediated gene therapy via multi-modality imaging

C. R. Haney, A. Parasca, Kazuhiro Ichikawa, M. Elas, M. Zamora, X. Fan, G. S. Karczmar, H. J. Mauceri, R. R. Weichselbaum, H. J. Halpern, C. A. Pelizzari

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Imaging techniques are under development which are intended to facilitate early analysis of spatial patterns of tumor response to combined radiation and antivascular gene therapy. We present initial results demonstrating treatment related changes of vascular permeability and blood volume maps using MRI, and tissue oxygenation measurements using electron paramagnetic resonance imaging (EPRI). Using a modified Kety model, the volume fraction accessible to the contrast agent was significantly greater in the tumor (0.81±0.11), compared to muscle (0.20±0.00, p < 0.05). However, the two compartment model is probably not able to account for accumulation of contrast agent in the tumor. A three compartment model may improve fitting.

    Original languageEnglish
    Title of host publication2004 2nd IEEE International Symposium on Biomedical Imaging
    Subtitle of host publicationMacro to Nano
    Pages1549-1552
    Number of pages4
    Publication statusPublished - Dec 1 2004
    Event2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano - Arlington, VA, United States
    Duration: Apr 15 2004Apr 18 2004

    Publication series

    Name2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
    Volume2

    Other

    Other2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
    CountryUnited States
    CityArlington, VA
    Period4/15/044/18/04

    Fingerprint

    Gene therapy
    Tumors
    Imaging techniques
    Radiation
    Oxygenation
    Magnetic resonance imaging
    Paramagnetic resonance
    Muscle
    Volume fraction
    Blood
    Tissue

    All Science Journal Classification (ASJC) codes

    • Engineering(all)

    Cite this

    Haney, C. R., Parasca, A., Ichikawa, K., Elas, M., Zamora, M., Fan, X., ... Pelizzari, C. A. (2004). Assessment of radiation mediated gene therapy via multi-modality imaging. In 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (pp. 1549-1552). (2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano; Vol. 2).

    Assessment of radiation mediated gene therapy via multi-modality imaging. / Haney, C. R.; Parasca, A.; Ichikawa, Kazuhiro; Elas, M.; Zamora, M.; Fan, X.; Karczmar, G. S.; Mauceri, H. J.; Weichselbaum, R. R.; Halpern, H. J.; Pelizzari, C. A.

    2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano. 2004. p. 1549-1552 (2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano; Vol. 2).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Haney, CR, Parasca, A, Ichikawa, K, Elas, M, Zamora, M, Fan, X, Karczmar, GS, Mauceri, HJ, Weichselbaum, RR, Halpern, HJ & Pelizzari, CA 2004, Assessment of radiation mediated gene therapy via multi-modality imaging. in 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano. 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano, vol. 2, pp. 1549-1552, 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano, Arlington, VA, United States, 4/15/04.
    Haney CR, Parasca A, Ichikawa K, Elas M, Zamora M, Fan X et al. Assessment of radiation mediated gene therapy via multi-modality imaging. In 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano. 2004. p. 1549-1552. (2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano).
    Haney, C. R. ; Parasca, A. ; Ichikawa, Kazuhiro ; Elas, M. ; Zamora, M. ; Fan, X. ; Karczmar, G. S. ; Mauceri, H. J. ; Weichselbaum, R. R. ; Halpern, H. J. ; Pelizzari, C. A. / Assessment of radiation mediated gene therapy via multi-modality imaging. 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano. 2004. pp. 1549-1552 (2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano).
    @inproceedings{af4545fa41ff4d83b2873a3b98a2fcdc,
    title = "Assessment of radiation mediated gene therapy via multi-modality imaging",
    abstract = "Imaging techniques are under development which are intended to facilitate early analysis of spatial patterns of tumor response to combined radiation and antivascular gene therapy. We present initial results demonstrating treatment related changes of vascular permeability and blood volume maps using MRI, and tissue oxygenation measurements using electron paramagnetic resonance imaging (EPRI). Using a modified Kety model, the volume fraction accessible to the contrast agent was significantly greater in the tumor (0.81±0.11), compared to muscle (0.20±0.00, p < 0.05). However, the two compartment model is probably not able to account for accumulation of contrast agent in the tumor. A three compartment model may improve fitting.",
    author = "Haney, {C. R.} and A. Parasca and Kazuhiro Ichikawa and M. Elas and M. Zamora and X. Fan and Karczmar, {G. S.} and Mauceri, {H. J.} and Weichselbaum, {R. R.} and Halpern, {H. J.} and Pelizzari, {C. A.}",
    year = "2004",
    month = "12",
    day = "1",
    language = "English",
    isbn = "0780383885",
    series = "2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano",
    pages = "1549--1552",
    booktitle = "2004 2nd IEEE International Symposium on Biomedical Imaging",

    }

    TY - GEN

    T1 - Assessment of radiation mediated gene therapy via multi-modality imaging

    AU - Haney, C. R.

    AU - Parasca, A.

    AU - Ichikawa, Kazuhiro

    AU - Elas, M.

    AU - Zamora, M.

    AU - Fan, X.

    AU - Karczmar, G. S.

    AU - Mauceri, H. J.

    AU - Weichselbaum, R. R.

    AU - Halpern, H. J.

    AU - Pelizzari, C. A.

    PY - 2004/12/1

    Y1 - 2004/12/1

    N2 - Imaging techniques are under development which are intended to facilitate early analysis of spatial patterns of tumor response to combined radiation and antivascular gene therapy. We present initial results demonstrating treatment related changes of vascular permeability and blood volume maps using MRI, and tissue oxygenation measurements using electron paramagnetic resonance imaging (EPRI). Using a modified Kety model, the volume fraction accessible to the contrast agent was significantly greater in the tumor (0.81±0.11), compared to muscle (0.20±0.00, p < 0.05). However, the two compartment model is probably not able to account for accumulation of contrast agent in the tumor. A three compartment model may improve fitting.

    AB - Imaging techniques are under development which are intended to facilitate early analysis of spatial patterns of tumor response to combined radiation and antivascular gene therapy. We present initial results demonstrating treatment related changes of vascular permeability and blood volume maps using MRI, and tissue oxygenation measurements using electron paramagnetic resonance imaging (EPRI). Using a modified Kety model, the volume fraction accessible to the contrast agent was significantly greater in the tumor (0.81±0.11), compared to muscle (0.20±0.00, p < 0.05). However, the two compartment model is probably not able to account for accumulation of contrast agent in the tumor. A three compartment model may improve fitting.

    UR - http://www.scopus.com/inward/record.url?scp=20244373497&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=20244373497&partnerID=8YFLogxK

    M3 - Conference contribution

    AN - SCOPUS:20244373497

    SN - 0780383885

    SN - 9780780383883

    T3 - 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano

    SP - 1549

    EP - 1552

    BT - 2004 2nd IEEE International Symposium on Biomedical Imaging

    ER -