Assessment of radiation mediated gene therapy via multi-modality imaging

C. R. Haney, A. Parasca, K. Ichikawa, M. Elas, M. Zamora, X. Fan, G. S. Karczmar, H. J. Mauceri, R. R. Weichselbaum, H. J. Halpern, C. A. Pelizzari

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Imaging techniques are under development which are intended to facilitate early analysis of spatial patterns of tumor response to combined radiation and antivascular gene therapy. We present initial results demonstrating treatment related changes of vascular permeability and blood volume maps using MRI, and tissue oxygenation measurements using electron paramagnetic resonance imaging (EPRI). Using a modified Kety model, the volume fraction accessible to the contrast agent was significantly greater in the tumor (0.81±0.11), compared to muscle (0.20±0.00, p < 0.05). However, the two compartment model is probably not able to account for accumulation of contrast agent in the tumor. A three compartment model may improve fitting.

    Original languageEnglish
    Title of host publication2004 2nd IEEE International Symposium on Biomedical Imaging
    Subtitle of host publicationMacro to Nano
    Pages1549-1552
    Number of pages4
    Publication statusPublished - 2004
    Event2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano - Arlington, VA, United States
    Duration: Apr 15 2004Apr 18 2004

    Publication series

    Name2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
    Volume2

    Other

    Other2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
    CountryUnited States
    CityArlington, VA
    Period4/15/044/18/04

    All Science Journal Classification (ASJC) codes

    • Engineering(all)

    Fingerprint Dive into the research topics of 'Assessment of radiation mediated gene therapy via multi-modality imaging'. Together they form a unique fingerprint.

    Cite this