Abstract
BACKGROUND: Night-time blood pressure (BP) is strongly associated with hypertensive target organ damage; however, no previous studies have compared home BP monitor measurements of the reduction in night-time BP induced by antihypertensive medications with those obtained with ambulatory BP monitors. METHODS: As part of the Japan Morning Surge-Target Organ Protection study, in which candesartan (thiazide diuretics were added, if needed) was administered to hypertensive patients in the morning or at bedtime, 50 hypertensive patients had their night-time home and ambulatory BP successfully measured at the baseline and 6 months. In addition, three night-time home BP readings were taken during sleeping hours (at 2, 3, and 4 o'clock) for 6 months. RESULTS: The mean reduction in night-time BP did not differ significantly between home and ambulatory BP monitoring (10.4±17.9/6.0±12.0 vs. 13.3±14.6/7.6±8.9mmHg, P=0.219/0.344), but the differences varied among individual patients. The reduction in night-time BP according to home BP monitoring was significantly correlated with the value obtained with ambulatory BP monitoring (r=0.51/0.38, P<0.001/=0.006). The reduction in night-time SBP according to home BP monitoring was significantly correlated with the reductions in left ventricular mass index (r=0.385, P=0.013, N=41) and Sokolow-Lyon voltage (r=0.335, P=0.035, N=40). CONCLUSION: Home BP monitoring produces estimates of mean night-time BP reductions comparable to those from ambulatory monitoring, while the differences varied among individual patients. The reduction in night-time home BP according to home BP monitoring is significantly correlated with the reduction in left ventricular hypertrophy.
| Original language | English |
|---|---|
| Pages (from-to) | 82-89 |
| Number of pages | 8 |
| Journal | Journal of Hypertension |
| Volume | 32 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2014 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
- Physiology
- Cardiology and Cardiovascular Medicine
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Assessment of the reductions in night-time blood pressure and dipping induced by antihypertensive medication using a home blood pressure monitor. / Ishikawa, Joji; Shimizu, Motohiro; Sugiyama Edison, Eijiro; Yano, Yuichiro; Hoshide, Satoshi; Eguchi, Kauzo; Kario, Kazuomi.
In: Journal of Hypertension, Vol. 32, No. 1, 01.01.2014, p. 82-89.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assessment of the reductions in night-time blood pressure and dipping induced by antihypertensive medication using a home blood pressure monitor
AU - Ishikawa, Joji
AU - Shimizu, Motohiro
AU - Sugiyama Edison, Eijiro
AU - Yano, Yuichiro
AU - Hoshide, Satoshi
AU - Eguchi, Kauzo
AU - Kario, Kazuomi
PY - 2014/1/1
Y1 - 2014/1/1
N2 - BACKGROUND: Night-time blood pressure (BP) is strongly associated with hypertensive target organ damage; however, no previous studies have compared home BP monitor measurements of the reduction in night-time BP induced by antihypertensive medications with those obtained with ambulatory BP monitors. METHODS: As part of the Japan Morning Surge-Target Organ Protection study, in which candesartan (thiazide diuretics were added, if needed) was administered to hypertensive patients in the morning or at bedtime, 50 hypertensive patients had their night-time home and ambulatory BP successfully measured at the baseline and 6 months. In addition, three night-time home BP readings were taken during sleeping hours (at 2, 3, and 4 o'clock) for 6 months. RESULTS: The mean reduction in night-time BP did not differ significantly between home and ambulatory BP monitoring (10.4±17.9/6.0±12.0 vs. 13.3±14.6/7.6±8.9mmHg, P=0.219/0.344), but the differences varied among individual patients. The reduction in night-time BP according to home BP monitoring was significantly correlated with the value obtained with ambulatory BP monitoring (r=0.51/0.38, P<0.001/=0.006). The reduction in night-time SBP according to home BP monitoring was significantly correlated with the reductions in left ventricular mass index (r=0.385, P=0.013, N=41) and Sokolow-Lyon voltage (r=0.335, P=0.035, N=40). CONCLUSION: Home BP monitoring produces estimates of mean night-time BP reductions comparable to those from ambulatory monitoring, while the differences varied among individual patients. The reduction in night-time home BP according to home BP monitoring is significantly correlated with the reduction in left ventricular hypertrophy.
AB - BACKGROUND: Night-time blood pressure (BP) is strongly associated with hypertensive target organ damage; however, no previous studies have compared home BP monitor measurements of the reduction in night-time BP induced by antihypertensive medications with those obtained with ambulatory BP monitors. METHODS: As part of the Japan Morning Surge-Target Organ Protection study, in which candesartan (thiazide diuretics were added, if needed) was administered to hypertensive patients in the morning or at bedtime, 50 hypertensive patients had their night-time home and ambulatory BP successfully measured at the baseline and 6 months. In addition, three night-time home BP readings were taken during sleeping hours (at 2, 3, and 4 o'clock) for 6 months. RESULTS: The mean reduction in night-time BP did not differ significantly between home and ambulatory BP monitoring (10.4±17.9/6.0±12.0 vs. 13.3±14.6/7.6±8.9mmHg, P=0.219/0.344), but the differences varied among individual patients. The reduction in night-time BP according to home BP monitoring was significantly correlated with the value obtained with ambulatory BP monitoring (r=0.51/0.38, P<0.001/=0.006). The reduction in night-time SBP according to home BP monitoring was significantly correlated with the reductions in left ventricular mass index (r=0.385, P=0.013, N=41) and Sokolow-Lyon voltage (r=0.335, P=0.035, N=40). CONCLUSION: Home BP monitoring produces estimates of mean night-time BP reductions comparable to those from ambulatory monitoring, while the differences varied among individual patients. The reduction in night-time home BP according to home BP monitoring is significantly correlated with the reduction in left ventricular hypertrophy.
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U2 - 10.1097/HJH.0b013e328365c8a8
DO - 10.1097/HJH.0b013e328365c8a8
M3 - Article
C2 - 24326992
AN - SCOPUS:84891557442
VL - 32
SP - 82
EP - 89
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 1
ER -