Assessment of tissue redox status using metabolic responsive contrast agents and magnetic resonance imaging

Fuminori Hyodo, Benjamin P. Soule, Ken Ichiro Matsumoto, Shingo Matusmoto, John A. Cook, Emi Hyodo, Anastasia L. Sowers, Murali C. Krishna, James B. Mitchell

    Research output: Contribution to journalReview articlepeer-review

    70 Citations (Scopus)

    Abstract

    Regulation of tissue redox status is important to maintain normal physiological conditions in the living body. Disruption of redox homoeostasis may lead to oxidative stress and can induce many pathological conditions such as cancer, neurological disorders and ageing. Therefore, imaging of tissue redox status could have clinical applications. Redox imaging employing magnetic resonance imaging (MRI) with nitroxides as cell-permeable redox-sensitive contrast agents has been used for non-invasive monitoring of tissue redox status in animal models. The redox imaging applications of nitroxide electron paramagnetic resonance imaging (EPRI) and MRI are reviewed here, with a focus on application of tumour redox status monitoring. While particular emphasis has been placed on differences in the redox status in tumours compared to selected normal tissues, the technique possesses the potential to have broad applications to the study of other disease states, inflammatory processes and other circumstances where oxidative stress is implicated.

    Original languageEnglish
    Pages (from-to)1049-1060
    Number of pages12
    JournalJournal of Pharmacy and Pharmacology
    Volume60
    Issue number8
    DOIs
    Publication statusPublished - Aug 2008

    All Science Journal Classification (ASJC) codes

    • Pharmacology
    • Pharmaceutical Science

    Fingerprint Dive into the research topics of 'Assessment of tissue redox status using metabolic responsive contrast agents and magnetic resonance imaging'. Together they form a unique fingerprint.

    Cite this