Intensified urbanization has caused a massive and uneven development in Makassar city. It affects to the lack of green area and growth of slum area. Thus, urban ecosystem health (UEH) is a first step toward assessing precisely the state of urban environmental quality by using geo-processing and spatial analyst tools in ArcGIS at regional scale. UEH indicator system was constructed to Pressure-State-Response (PSR) model with 16 assessment indicators. It was designated from extremely poor to very good condition to transfer the status of 139 sub-districts. As a result, from the perspective of spatial distribution, the city's UEH stand at normal and good condition with 44 and 36 sub-districts, 29.99% and 43.88% respectively. Meanwhile, the very good value of PSR factors mostly reached in response factors which indicates the enthusiastically awareness from government policy to overcome the environmental conditions and to improve management and quality of infrastructure.