Association between alkaline phosphatase and anemia in rural Japanese men: The Nagasaki Islands study

Yuji Shimizu, Mio Nakazato, Takaharu Sekita, Koichiro Kadota, Shimpei Sato, Kazuhiko Arima, Noboru Takamura, Kiyoshi Aoyagi, Yosuke Kusano, Takahiro Maeda

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3 Citations (Scopus)


Although bone metabolism is reportedly associated with production and maturation of blood corpuscles, and serum alkaline phosphatase (ALP) levels have been associated with bone metabolism, no published study has investigated the association between ALP and anemia. Furthermore, although ALP is known as an enzyme affected by alcohol consumption, there are no reports in the literature on associations between ALP and the risk of anemia in relation to drinking status. We conducted a cross-sectional study of 907 men aged 30-89 years undergoing a general health check-up to investigate the associations between ALP and anemia in relation to drinking status. Of the 907 participants, 120 men were diagnosed with anemia. The association between ALP and anemia was J-shaped. With the second quartile of ALP (194-228 IU/L) (Q2) as the reference group, the multivariable adjusted OR and 95%CI for anemia were 1.91 (95%CI: 0.96-3.82) for <194 IU/L (Q1), 1.84 (95%CI: 0.93-3.62) for 229-277 IU/L (Q3) and 2.83 (95%CI:1.49-5.37) for >277 IU/L (Q4). When the analysis was limited to non-drinkers, the associations became stronger with corresponding values of 3.34 (95%CI: 1.28-8.74), 3.18 (95%CI: 1.28-7.88) and 3.22 (95%CI:1.37-7.59). Not only lower but also higher levels of serum ALP are associated with anemia for men, especially non-drinkers. For analyses of associations between ALP and anemia, alcohol consumption should thus be considered a potential confounder.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalActa Medica Nagasakiensia
Issue number4
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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