Association between an HLA haplotype and low responsiveness to schistosomal worm antigen in man

Takehiko Sasazuki, N. Ohta, R. Kaneoka, S. Kojima

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Immune responsiveness to schistosomal worm antigen was investigated in the individuals infected with Schistosoma japonicum by measuring the antigen-specific proliferative response of the peripheral T lymphocytes in vitro. Out of 57 infected individuals, 10 (17.5%) were low responders, whereas 47 (82.5%) were high responders to this antigen. The strong association between the HLA-Aw24-Bw52-DwI2 haplotype and the low responder group was demonstrated. Because the association of the low responder group was strongest with the HLA-D specificity, Dw12, and because the HLA-D region was assumed to be comparable to the I region of the murine H-2 complex, it was suggested that the low responsiveness to schistosomal worm antigen was controlled by a single dominant imune suppresssion gene that was in strong linkage disequilibrium with HLA-Dw12.

Original languageEnglish
Pages (from-to)314-318
Number of pages5
JournalJournal of Experimental Medicine
Volume152
Issue number2 II
Publication statusPublished - Jan 1 1980
Externally publishedYes

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Haplotypes
HLA-D Antigens
Antigens
Schistosoma japonicum
Linkage Disequilibrium
T-Lymphocytes
Genes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Association between an HLA haplotype and low responsiveness to schistosomal worm antigen in man. / Sasazuki, Takehiko; Ohta, N.; Kaneoka, R.; Kojima, S.

In: Journal of Experimental Medicine, Vol. 152, No. 2 II, 01.01.1980, p. 314-318.

Research output: Contribution to journalArticle

Sasazuki, T, Ohta, N, Kaneoka, R & Kojima, S 1980, 'Association between an HLA haplotype and low responsiveness to schistosomal worm antigen in man', Journal of Experimental Medicine, vol. 152, no. 2 II, pp. 314-318.
Sasazuki, Takehiko ; Ohta, N. ; Kaneoka, R. ; Kojima, S. / Association between an HLA haplotype and low responsiveness to schistosomal worm antigen in man. In: Journal of Experimental Medicine. 1980 ; Vol. 152, No. 2 II. pp. 314-318.
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