Association between an HLA haplotype and low responsiveness to tetanus toxoid in man

T. Sasazuki, Y. Kohno, I. Iwamoto, M. Tanimura, S. Naito

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64 Citations (Scopus)

Abstract

THE major histocompatibility complex (MHC) in man, the HLA gene complex, has been assumed to code not only for histocompatibility antigens but also for immune responsiveness and control of disease susceptibility1. Although several attempts have been made to delineate the existence of HLA-linked immune response genes (Ir genes) in man, the data are controversial2-6. We demonstrate here a striking association between a particular HLA haplotype and low responsiveness to tetanus toxoid in vitro, which suggests that immune suppression genes exist in man.

Original languageEnglish
Number of pages1
JournalNature
Volume272
Issue number5651
DOIs
Publication statusPublished - Dec 1 1978
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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    Sasazuki, T., Kohno, Y., Iwamoto, I., Tanimura, M., & Naito, S. (1978). Association between an HLA haplotype and low responsiveness to tetanus toxoid in man. Nature, 272(5651). https://doi.org/10.1038/272359b0