Association between aqueous flare and epiretinal membrane in retinitis pigmentosa

Kohta Fujiwara, Yasuhiro Ikeda, Yusuke Murakami, Shunji Nakatake, Takashi Tachibana, Noriko Yoshida, Shintaro Nakao, Toshio Hisatomi, Shigeo Yoshida, Takeshi Yoshitomi, Koh Hei Sonoda, Tatsuro Ishibashi

Research output: Contribution to journalArticle

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Abstract

PURPOSE. Epiretinal membrane (ERM) is a frequent macular complication in patients with retinitis pigmentosa (RP). The etiology of ERM formation in RP is largely unknown. The purpose of this study was to investigate the association between aqueous flare, a surrogate index of intraocular inflammation, and ERM secondary to RP. METHODS. We retrospectively studied a total of 206 eyes of 117 patients who were diagnosed with typical RP. Aqueous flare values were measured consecutively in 2012 and 2013 using a laser flare cell meter. Spectral-domain optical coherence tomography images and fundus photographs taken on the same day of the aqueous flare measurements were analyzed for ERM detection. RESULTS. The mean values of aqueous flare, age, and frequency of male sex were significantly higher in the RP patients with ERM compared with the RP patients without ERM (P < 0.0001, P = 0.007, and P = 0.004, respectively). After adjustment for age and sex, the eyes in the highest quartile of aqueous flare had significantly higher odds of having ERM than those in the lowest quartile (odds ratio [OR], 2.68; 95% confidence interval [CI], 1.04-6.93), and the linear trend across flare levels was significant (P = 0.005). In addition, each 1-log-transformed increase in flare values was associated with an elevation of the likelihood of having ERM (OR, 2.59; 95% CI, 1.33-5.06). CONCLUSIONS. Our analysis demonstrated that elevated aqueous flare is associated with ERM secondary to RP, suggesting that inflammation may be implicated in the pathogenesis of ERM formation in RP.

Original languageEnglish
Pages (from-to)4282-4286
Number of pages5
JournalInvestigative Ophthalmology and Visual Science
Volume57
Issue number10
DOIs
Publication statusPublished - Aug 2016

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Epiretinal Membrane
Retinitis Pigmentosa
Aqueous Humor
Odds Ratio
Confidence Intervals
Inflammation
Optical Coherence Tomography
Lasers

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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Association between aqueous flare and epiretinal membrane in retinitis pigmentosa. / Fujiwara, Kohta; Ikeda, Yasuhiro; Murakami, Yusuke; Nakatake, Shunji; Tachibana, Takashi; Yoshida, Noriko; Nakao, Shintaro; Hisatomi, Toshio; Yoshida, Shigeo; Yoshitomi, Takeshi; Sonoda, Koh Hei; Ishibashi, Tatsuro.

In: Investigative Ophthalmology and Visual Science, Vol. 57, No. 10, 08.2016, p. 4282-4286.

Research output: Contribution to journalArticle

Fujiwara, Kohta ; Ikeda, Yasuhiro ; Murakami, Yusuke ; Nakatake, Shunji ; Tachibana, Takashi ; Yoshida, Noriko ; Nakao, Shintaro ; Hisatomi, Toshio ; Yoshida, Shigeo ; Yoshitomi, Takeshi ; Sonoda, Koh Hei ; Ishibashi, Tatsuro. / Association between aqueous flare and epiretinal membrane in retinitis pigmentosa. In: Investigative Ophthalmology and Visual Science. 2016 ; Vol. 57, No. 10. pp. 4282-4286.
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abstract = "PURPOSE. Epiretinal membrane (ERM) is a frequent macular complication in patients with retinitis pigmentosa (RP). The etiology of ERM formation in RP is largely unknown. The purpose of this study was to investigate the association between aqueous flare, a surrogate index of intraocular inflammation, and ERM secondary to RP. METHODS. We retrospectively studied a total of 206 eyes of 117 patients who were diagnosed with typical RP. Aqueous flare values were measured consecutively in 2012 and 2013 using a laser flare cell meter. Spectral-domain optical coherence tomography images and fundus photographs taken on the same day of the aqueous flare measurements were analyzed for ERM detection. RESULTS. The mean values of aqueous flare, age, and frequency of male sex were significantly higher in the RP patients with ERM compared with the RP patients without ERM (P < 0.0001, P = 0.007, and P = 0.004, respectively). After adjustment for age and sex, the eyes in the highest quartile of aqueous flare had significantly higher odds of having ERM than those in the lowest quartile (odds ratio [OR], 2.68; 95{\%} confidence interval [CI], 1.04-6.93), and the linear trend across flare levels was significant (P = 0.005). In addition, each 1-log-transformed increase in flare values was associated with an elevation of the likelihood of having ERM (OR, 2.59; 95{\%} CI, 1.33-5.06). CONCLUSIONS. Our analysis demonstrated that elevated aqueous flare is associated with ERM secondary to RP, suggesting that inflammation may be implicated in the pathogenesis of ERM formation in RP.",
author = "Kohta Fujiwara and Yasuhiro Ikeda and Yusuke Murakami and Shunji Nakatake and Takashi Tachibana and Noriko Yoshida and Shintaro Nakao and Toshio Hisatomi and Shigeo Yoshida and Takeshi Yoshitomi and Sonoda, {Koh Hei} and Tatsuro Ishibashi",
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T1 - Association between aqueous flare and epiretinal membrane in retinitis pigmentosa

AU - Fujiwara, Kohta

AU - Ikeda, Yasuhiro

AU - Murakami, Yusuke

AU - Nakatake, Shunji

AU - Tachibana, Takashi

AU - Yoshida, Noriko

AU - Nakao, Shintaro

AU - Hisatomi, Toshio

AU - Yoshida, Shigeo

AU - Yoshitomi, Takeshi

AU - Sonoda, Koh Hei

AU - Ishibashi, Tatsuro

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N2 - PURPOSE. Epiretinal membrane (ERM) is a frequent macular complication in patients with retinitis pigmentosa (RP). The etiology of ERM formation in RP is largely unknown. The purpose of this study was to investigate the association between aqueous flare, a surrogate index of intraocular inflammation, and ERM secondary to RP. METHODS. We retrospectively studied a total of 206 eyes of 117 patients who were diagnosed with typical RP. Aqueous flare values were measured consecutively in 2012 and 2013 using a laser flare cell meter. Spectral-domain optical coherence tomography images and fundus photographs taken on the same day of the aqueous flare measurements were analyzed for ERM detection. RESULTS. The mean values of aqueous flare, age, and frequency of male sex were significantly higher in the RP patients with ERM compared with the RP patients without ERM (P < 0.0001, P = 0.007, and P = 0.004, respectively). After adjustment for age and sex, the eyes in the highest quartile of aqueous flare had significantly higher odds of having ERM than those in the lowest quartile (odds ratio [OR], 2.68; 95% confidence interval [CI], 1.04-6.93), and the linear trend across flare levels was significant (P = 0.005). In addition, each 1-log-transformed increase in flare values was associated with an elevation of the likelihood of having ERM (OR, 2.59; 95% CI, 1.33-5.06). CONCLUSIONS. Our analysis demonstrated that elevated aqueous flare is associated with ERM secondary to RP, suggesting that inflammation may be implicated in the pathogenesis of ERM formation in RP.

AB - PURPOSE. Epiretinal membrane (ERM) is a frequent macular complication in patients with retinitis pigmentosa (RP). The etiology of ERM formation in RP is largely unknown. The purpose of this study was to investigate the association between aqueous flare, a surrogate index of intraocular inflammation, and ERM secondary to RP. METHODS. We retrospectively studied a total of 206 eyes of 117 patients who were diagnosed with typical RP. Aqueous flare values were measured consecutively in 2012 and 2013 using a laser flare cell meter. Spectral-domain optical coherence tomography images and fundus photographs taken on the same day of the aqueous flare measurements were analyzed for ERM detection. RESULTS. The mean values of aqueous flare, age, and frequency of male sex were significantly higher in the RP patients with ERM compared with the RP patients without ERM (P < 0.0001, P = 0.007, and P = 0.004, respectively). After adjustment for age and sex, the eyes in the highest quartile of aqueous flare had significantly higher odds of having ERM than those in the lowest quartile (odds ratio [OR], 2.68; 95% confidence interval [CI], 1.04-6.93), and the linear trend across flare levels was significant (P = 0.005). In addition, each 1-log-transformed increase in flare values was associated with an elevation of the likelihood of having ERM (OR, 2.59; 95% CI, 1.33-5.06). CONCLUSIONS. Our analysis demonstrated that elevated aqueous flare is associated with ERM secondary to RP, suggesting that inflammation may be implicated in the pathogenesis of ERM formation in RP.

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