Association between asthma and an intragenic variant of CC16 on chromosome 11q13

X. Q. Mao; T. Shirakawa; M. Kawai; T. Enomoto; S. Sasaki; Y. Dake; H. Kitano; A. Hagihara; J. M. Hopkin; K. Morimoto

doi:10.1111/j.1399-0004.1998.tb02582.x

Association between asthma and an intragenic variant of CC16 on chromosome 11q13

X. Q. Mao, T. Shirakawa, M. Kawai, T. Enomoto, S. Sasaki, Y. Dake, H. Kitano, A. Hagihara, J. M. Hopkin, K. Morimoto

Health Care Administration and Management

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23 Citations (Scopus)

Abstract

The β subunit of high affinity immunoglobulin E (IgE) receptor (FcεRIβ) and the Clara cell derived inflammatory molecule, CC16 have been cited as candidate genes for atopic asthma on chromosome 11q13. A genetic association study was performed with an intragenic microsatellite repeat of CC16 gene on chromosome 11q12-13 in relation to atopic and non-atopic asthma. Whereas variants of FcεRIβ at chromosome 11q13 show association with atopy and asthma, no significant association was found between asthma and CC16 genotypes irrespective of atopic status. These data support the candidacy of FcεRIβ rather than CC16 for the atopic asthma locus on chromosome 11q.

Original language	English
Pages (from-to)	54-56
Number of pages	3
Journal	Clinical Genetics
Volume	53
Issue number	1
DOIs	https://doi.org/10.1111/j.1399-0004.1998.tb02582.x
Publication status	Published - Jan 1998

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)

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10.1111/j.1399-0004.1998.tb02582.x

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abstract = "The β subunit of high affinity immunoglobulin E (IgE) receptor (FcεRIβ) and the Clara cell derived inflammatory molecule, CC16 have been cited as candidate genes for atopic asthma on chromosome 11q13. A genetic association study was performed with an intragenic microsatellite repeat of CC16 gene on chromosome 11q12-13 in relation to atopic and non-atopic asthma. Whereas variants of FcεRIβ at chromosome 11q13 show association with atopy and asthma, no significant association was found between asthma and CC16 genotypes irrespective of atopic status. These data support the candidacy of FcεRIβ rather than CC16 for the atopic asthma locus on chromosome 11q.",

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AU - Mao, X. Q.

AU - Shirakawa, T.

AU - Kawai, M.

AU - Enomoto, T.

AU - Sasaki, S.

AU - Dake, Y.

AU - Kitano, H.

AU - Hagihara, A.

AU - Hopkin, J. M.

AU - Morimoto, K.

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AB - The β subunit of high affinity immunoglobulin E (IgE) receptor (FcεRIβ) and the Clara cell derived inflammatory molecule, CC16 have been cited as candidate genes for atopic asthma on chromosome 11q13. A genetic association study was performed with an intragenic microsatellite repeat of CC16 gene on chromosome 11q12-13 in relation to atopic and non-atopic asthma. Whereas variants of FcεRIβ at chromosome 11q13 show association with atopy and asthma, no significant association was found between asthma and CC16 genotypes irrespective of atopic status. These data support the candidacy of FcεRIβ rather than CC16 for the atopic asthma locus on chromosome 11q.

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Association between asthma and an intragenic variant of CC16 on chromosome 11q13

Abstract

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