Association between asthma and an intragenic variant of CC16 on chromosome 11q13

X. Q. Mao, T. Shirakawa, M. Kawai, T. Enomoto, S. Sasaki, Y. Dake, H. Kitano, A. Hagihara, J. M. Hopkin, K. Morimoto

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Abstract

The β subunit of high affinity immunoglobulin E (IgE) receptor (FcεRIβ) and the Clara cell derived inflammatory molecule, CC16 have been cited as candidate genes for atopic asthma on chromosome 11q13. A genetic association study was performed with an intragenic microsatellite repeat of CC16 gene on chromosome 11q12-13 in relation to atopic and non-atopic asthma. Whereas variants of FcεRIβ at chromosome 11q13 show association with atopy and asthma, no significant association was found between asthma and CC16 genotypes irrespective of atopic status. These data support the candidacy of FcεRIβ rather than CC16 for the atopic asthma locus on chromosome 11q.

Original languageEnglish
Pages (from-to)54-56
Number of pages3
JournalClinical Genetics
Volume53
Issue number1
Publication statusPublished - Jan 1 1998

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All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Mao, X. Q., Shirakawa, T., Kawai, M., Enomoto, T., Sasaki, S., Dake, Y., ... Morimoto, K. (1998). Association between asthma and an intragenic variant of CC16 on chromosome 11q13. Clinical Genetics, 53(1), 54-56.