Association between body weight at weaning and remodeling in the subcutaneous adipose tissue of obese adult mice with undernourishment in utero

Yukiko Kobayashi Kohmura, Naohiro Kanayama, Keiko Muramatsu, Naoaki Tamura, Chizuko Yaguchi, Toshiyuki Uchida, Kazunao Suzuki, Kazuhiro Sugihara, Seiichiro Aoe, Takeshi Sasaki, Takayoshi Suganami, Yoshihiro Ogawa, Hiroaki Itoh

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Rapid growth in infancy considerably increases the risk of obesity and metabolic disorders in adulthood especially among neonates born small. To investigate the mechanism involved, we developed an animal model of undernourishment in utero by maternal caloric restriction, in which the Z scores of body weight at weaning (19.5 days) positively correlated with parameters of obesity, metabolic disorders, and remodeling of subcutaneous adipose tissue, such as numbers of macrophages in adipose tissue, the ratio of inflammatory M1 to anti-inflammatory M2 macrophages, estimated by gene expression of specific antigens, and the relative ratio of small adipocytes less than 30 μm in diameter, on a high-fat diet at 17 weeks of age. To our knowledge, this is the first report of a possible connection between infantile body weight and adipose tissue remodeling in obesity after undernourishment in utero.

Original languageEnglish
Pages (from-to)813-827
Number of pages15
JournalReproductive Sciences
Volume20
Issue number7
DOIs
Publication statusPublished - Jul 1 2013

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Obese Mice
Subcutaneous Fat
Weaning
Obesity
Body Weight
Adipose Tissue
Macrophages
Caloric Restriction
High Fat Diet
Adipocytes
Anti-Inflammatory Agents
Animal Models
Mothers
Newborn Infant
Gene Expression
Antigens
Growth

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Association between body weight at weaning and remodeling in the subcutaneous adipose tissue of obese adult mice with undernourishment in utero. / Kohmura, Yukiko Kobayashi; Kanayama, Naohiro; Muramatsu, Keiko; Tamura, Naoaki; Yaguchi, Chizuko; Uchida, Toshiyuki; Suzuki, Kazunao; Sugihara, Kazuhiro; Aoe, Seiichiro; Sasaki, Takeshi; Suganami, Takayoshi; Ogawa, Yoshihiro; Itoh, Hiroaki.

In: Reproductive Sciences, Vol. 20, No. 7, 01.07.2013, p. 813-827.

Research output: Contribution to journalArticle

Kohmura, YK, Kanayama, N, Muramatsu, K, Tamura, N, Yaguchi, C, Uchida, T, Suzuki, K, Sugihara, K, Aoe, S, Sasaki, T, Suganami, T, Ogawa, Y & Itoh, H 2013, 'Association between body weight at weaning and remodeling in the subcutaneous adipose tissue of obese adult mice with undernourishment in utero', Reproductive Sciences, vol. 20, no. 7, pp. 813-827. https://doi.org/10.1177/1933719112466300
Kohmura, Yukiko Kobayashi ; Kanayama, Naohiro ; Muramatsu, Keiko ; Tamura, Naoaki ; Yaguchi, Chizuko ; Uchida, Toshiyuki ; Suzuki, Kazunao ; Sugihara, Kazuhiro ; Aoe, Seiichiro ; Sasaki, Takeshi ; Suganami, Takayoshi ; Ogawa, Yoshihiro ; Itoh, Hiroaki. / Association between body weight at weaning and remodeling in the subcutaneous adipose tissue of obese adult mice with undernourishment in utero. In: Reproductive Sciences. 2013 ; Vol. 20, No. 7. pp. 813-827.
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