Association between circulating CD34- positive cells and serum alkaline phosphatase in relation to body mass index for elderly Japanese men

Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Koichiro Kadota, Kazuto Tsuruda, Naomi Hayashida, Norio Abiru, Hironori Yamasaki, Noboru Takamura, Takahiro Maeda

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Recent studies have confirmed an association between bone metabolism and vascular homeostasis. However, no study has examined the relationship between serum alkaline phosphatase (ALP) (a marker of bone metabolism) and circulating immature cell such as CD34-positive cells (a marker of vascular homeostasis). Methods: We conducted a cross-sectional study of this association in 272 elderly Japanese men (60-79 years). Because low body mass index (BMI) status is a known characteristic of Japanese with a high incidence rate of stroke, we used a stratified analysis based on BMI. Results: Multivariable linear regression analysis adjusted for confounding factors showed a significant correlation between serum ALP and the number of circulating CD34-positive cells, especially for participants with low BMI (<23 kg/m2). The parameter estimates (β) and 95 % confidence intervals (CI) for one standard deviation increments in serum ALP levels (62 IU/L) for the circulating CD34-positive cell count were β = 0.25 (0.04, 0.45) for total subjects, β = 0.45 (0.16, 0.75) for participants with low BMI (<23 kg/m2), and β = 0.04 (-0.25, 0.34) for participants with high BMI (≥23 kg/m2). Conclusion: Serum ALP correlates positively with circulating CD34-positive cells among a general population of elderly Japanese men, especially those with low BMI (<23 kg/m2). These findings suggest that serum ALP levels may constitute an efficient tool for estimating the risk of insufficient vascular homeostasis, especially for participants with relatively few classical cardiovascular risk factors.

Original languageEnglish
Article number2
JournalJournal of physiological anthropology
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 14 2016

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Phosphatases
Alkaline Phosphatase
Body Mass Index
Cells
Serum
Blood Vessels
Homeostasis
Metabolism
Bone
Bone and Bones
Linear regression
Regression analysis
stroke
cross-sectional study
Linear Models
regression analysis
incidence
Cell Count
Cross-Sectional Studies
confidence

All Science Journal Classification (ASJC) codes

  • Human Factors and Ergonomics
  • Physiology
  • Orthopedics and Sports Medicine
  • Anthropology
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)

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Association between circulating CD34- positive cells and serum alkaline phosphatase in relation to body mass index for elderly Japanese men. / Shimizu, Yuji; Sato, Shimpei; Koyamatsu, Jun; Yamanashi, Hirotomo; Nagayoshi, Mako; Kadota, Koichiro; Tsuruda, Kazuto; Hayashida, Naomi; Abiru, Norio; Yamasaki, Hironori; Takamura, Noboru; Maeda, Takahiro.

In: Journal of physiological anthropology, Vol. 35, No. 1, 2, 14.01.2016.

Research output: Contribution to journalArticle

Shimizu, Y, Sato, S, Koyamatsu, J, Yamanashi, H, Nagayoshi, M, Kadota, K, Tsuruda, K, Hayashida, N, Abiru, N, Yamasaki, H, Takamura, N & Maeda, T 2016, 'Association between circulating CD34- positive cells and serum alkaline phosphatase in relation to body mass index for elderly Japanese men', Journal of physiological anthropology, vol. 35, no. 1, 2. https://doi.org/10.1186/s40101-016-0084-8
Shimizu, Yuji ; Sato, Shimpei ; Koyamatsu, Jun ; Yamanashi, Hirotomo ; Nagayoshi, Mako ; Kadota, Koichiro ; Tsuruda, Kazuto ; Hayashida, Naomi ; Abiru, Norio ; Yamasaki, Hironori ; Takamura, Noboru ; Maeda, Takahiro. / Association between circulating CD34- positive cells and serum alkaline phosphatase in relation to body mass index for elderly Japanese men. In: Journal of physiological anthropology. 2016 ; Vol. 35, No. 1.
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AU - Shimizu, Yuji

AU - Sato, Shimpei

AU - Koyamatsu, Jun

AU - Yamanashi, Hirotomo

AU - Nagayoshi, Mako

AU - Kadota, Koichiro

AU - Tsuruda, Kazuto

AU - Hayashida, Naomi

AU - Abiru, Norio

AU - Yamasaki, Hironori

AU - Takamura, Noboru

AU - Maeda, Takahiro

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N2 - Background: Recent studies have confirmed an association between bone metabolism and vascular homeostasis. However, no study has examined the relationship between serum alkaline phosphatase (ALP) (a marker of bone metabolism) and circulating immature cell such as CD34-positive cells (a marker of vascular homeostasis). Methods: We conducted a cross-sectional study of this association in 272 elderly Japanese men (60-79 years). Because low body mass index (BMI) status is a known characteristic of Japanese with a high incidence rate of stroke, we used a stratified analysis based on BMI. Results: Multivariable linear regression analysis adjusted for confounding factors showed a significant correlation between serum ALP and the number of circulating CD34-positive cells, especially for participants with low BMI (<23 kg/m2). The parameter estimates (β) and 95 % confidence intervals (CI) for one standard deviation increments in serum ALP levels (62 IU/L) for the circulating CD34-positive cell count were β = 0.25 (0.04, 0.45) for total subjects, β = 0.45 (0.16, 0.75) for participants with low BMI (<23 kg/m2), and β = 0.04 (-0.25, 0.34) for participants with high BMI (≥23 kg/m2). Conclusion: Serum ALP correlates positively with circulating CD34-positive cells among a general population of elderly Japanese men, especially those with low BMI (<23 kg/m2). These findings suggest that serum ALP levels may constitute an efficient tool for estimating the risk of insufficient vascular homeostasis, especially for participants with relatively few classical cardiovascular risk factors.

AB - Background: Recent studies have confirmed an association between bone metabolism and vascular homeostasis. However, no study has examined the relationship between serum alkaline phosphatase (ALP) (a marker of bone metabolism) and circulating immature cell such as CD34-positive cells (a marker of vascular homeostasis). Methods: We conducted a cross-sectional study of this association in 272 elderly Japanese men (60-79 years). Because low body mass index (BMI) status is a known characteristic of Japanese with a high incidence rate of stroke, we used a stratified analysis based on BMI. Results: Multivariable linear regression analysis adjusted for confounding factors showed a significant correlation between serum ALP and the number of circulating CD34-positive cells, especially for participants with low BMI (<23 kg/m2). The parameter estimates (β) and 95 % confidence intervals (CI) for one standard deviation increments in serum ALP levels (62 IU/L) for the circulating CD34-positive cell count were β = 0.25 (0.04, 0.45) for total subjects, β = 0.45 (0.16, 0.75) for participants with low BMI (<23 kg/m2), and β = 0.04 (-0.25, 0.34) for participants with high BMI (≥23 kg/m2). Conclusion: Serum ALP correlates positively with circulating CD34-positive cells among a general population of elderly Japanese men, especially those with low BMI (<23 kg/m2). These findings suggest that serum ALP levels may constitute an efficient tool for estimating the risk of insufficient vascular homeostasis, especially for participants with relatively few classical cardiovascular risk factors.

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