Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects

Yutaka Ono, Hiroshi Manki, Kimio Yoshimura, Taro Muramatsu, Hiroko Mizushima, Susumu Higuchi, Gohei Yagi, Shigenobu Kanba, Masahiro Asai

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

This study was designed to assess the association between novelty seeking and D4DR gene polymorphism in the Japanese population. The 48 bp repeat polymorphism in the third exon of the dopamine D4 receptor gene of 153 normal female students was correlated with personality feature results from the Japanese version of Cloninger's Temperament and Character Inventory. The Novelty Seeking subscale of Exploratory Excitability had a significant association with long alleles of the polymorphic exon III repeat sequence of D4DR. Our results suggest that there is an association between long alleles of the polymorphic exon III repeat sequence of D4DR and the personality traits of the Novelty Seeking subscale of Exploratory Excitability, regardless of racial differences in the frequencies of D4DR exon III repeat polymorphism.

Original languageEnglish
Pages (from-to)501-503
Number of pages3
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume74
Issue number5
DOIs
Publication statusPublished - Oct 15 1997

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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