Association between EGFR-TKI resistance and efficacy of radiotherapy for brain metastases from EGFR-mutant lung adenocarcinoma

Hidenari Hirata, Katsumasa Nakamura, Naonobu Kunitake, Yoshiyuki Shioyama, Tomonari Sasaki, Saiji Ohga, Takeshi Nonoshita, Tadamasa Yoshitake, Kaori Asai, Kouji Inoue, Akira Nagashima, Minoru Ono, Hiroshi Honda

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Aim: To clarify how patients with epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma with acquired resistance to EGFR-tyrosine kinase inhibitors (TKIs) respond to radiotherapy (RT) for brain metastases. Patients and Methods: Forty-seven patients were divided into the following three groups: a TKI-naïve group with EGFR mutation (n=11), a TKI-resistant group with EGFR mutation (n=10), and an EGFR-wild-type group (n=26). Patients received stereotactic RT (n=23) or whole-brain RT (n=24). Results: The response rate for patients with TKI-resistant tumor at three months after RT tended to be lower (11%) than that of those who were TKI-naïve (82%, p=0.006) and for patients with wild-type EGFR (48%, p=0.10). On univariate analysis, central nervous system progression-free and overall survival were significantly shorter for patients with TKI-resistant tumors than for those who were TKI-naïve (p=0.018 and p=0.005, respectively). Multivariate analysis showed that TKI resistance was an independent predictor of poorer overall survival (p=0.011). Conclusion: Acquired resistance to TKIs appears to be associated with low efficacy of brain RT.

Original languageEnglish
Pages (from-to)1649-1656
Number of pages8
JournalAnticancer research
Volume33
Issue number4
Publication statusPublished - Apr 2013

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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