Association between exposure to air pollution during pregnancy and false positives in fetal heart rate monitoring

Seiichi Morokuma, Takehiro Michikawa, Shin Yamazaki, Hiroshi Nitta, Kiyoko Kato

Research output: Contribution to journalArticle

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Abstract

Fetal heart rate (FHR) monitoring is essential for fetal management during pregnancy and delivery but results in many false-positive diagnoses. Air pollution affects the uterine environment; thus, air pollution may change FHR reactivity. This study assessed the association between exposure to air pollution during pregnancy and FHR monitoring abnormalities using 2005-2010 data from the Japan Perinatal Registry Network database. Participants were 23,782 singleton pregnant women with FHR monitoring, without acidemia or fetal asphyxia. We assessed exposure to air pollutants, including particulate matter (PM), ozone, nitrogen dioxide (NO2), and sulfur dioxide (SO2). In a multi-trimester model, first-trimester PM exposure was associated with false positives in FHR monitoring (odds ratio [OR] per interquartile range (10.7 μg/m3) increase = 1.20; 95% CI: 1.05-1.37), but not second-trimester exposure (OR = 1.05; 95% CI: 0.91-1.21) and third-trimester exposure (OR = 1.06; 95% CI: 0.96-1.17). The association with first-trimester PM exposure persisted after adjustment for exposure to ozone, NO2, and SO2; however, ozone, NO2, and SO2 exposure was not associated with false positives in FHR monitoring. First-trimester PM exposure may alter fetal cardiac response and lead to false positives in FHR monitoring.

Original languageEnglish
Article number12421
JournalScientific reports
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 1 2017

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Fetal Heart Rate
Air Pollution
Particulate Matter
Pregnancy
Ozone
First Pregnancy Trimester
Odds Ratio
Nitrogen Dioxide
Sulfur Dioxide
Air Pollutants
Asphyxia
Third Pregnancy Trimester
Second Pregnancy Trimester
Registries
Pregnant Women
Japan
Databases

All Science Journal Classification (ASJC) codes

  • General

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Association between exposure to air pollution during pregnancy and false positives in fetal heart rate monitoring. / Morokuma, Seiichi; Michikawa, Takehiro; Yamazaki, Shin; Nitta, Hiroshi; Kato, Kiyoko.

In: Scientific reports, Vol. 7, No. 1, 12421, 01.12.2017.

Research output: Contribution to journalArticle

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abstract = "Fetal heart rate (FHR) monitoring is essential for fetal management during pregnancy and delivery but results in many false-positive diagnoses. Air pollution affects the uterine environment; thus, air pollution may change FHR reactivity. This study assessed the association between exposure to air pollution during pregnancy and FHR monitoring abnormalities using 2005-2010 data from the Japan Perinatal Registry Network database. Participants were 23,782 singleton pregnant women with FHR monitoring, without acidemia or fetal asphyxia. We assessed exposure to air pollutants, including particulate matter (PM), ozone, nitrogen dioxide (NO2), and sulfur dioxide (SO2). In a multi-trimester model, first-trimester PM exposure was associated with false positives in FHR monitoring (odds ratio [OR] per interquartile range (10.7 μg/m3) increase = 1.20; 95{\%} CI: 1.05-1.37), but not second-trimester exposure (OR = 1.05; 95{\%} CI: 0.91-1.21) and third-trimester exposure (OR = 1.06; 95{\%} CI: 0.96-1.17). The association with first-trimester PM exposure persisted after adjustment for exposure to ozone, NO2, and SO2; however, ozone, NO2, and SO2 exposure was not associated with false positives in FHR monitoring. First-trimester PM exposure may alter fetal cardiac response and lead to false positives in FHR monitoring.",
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