Association between fever and serum interleukin-6 levels in children with group a β-hemolytic streptococcal infection

Shouichi Ohga, Mari Nishizaki, Takako Nagashima, Kohji Ueda

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1. 1|The serum levels of interleukin (IL)-1β, IL-6 and granulocyte colony-stimulating factor (G-CSF) were measured in children with Group A β-hemolytic streptococcal (GABHS) infection using sensitive immunoassays. 2. 2|Serum IL-6 levels were elevated in 21 27 patients during the phase of GABHS antigen-detection, significantly higher than in healthy control children (P < 0.01). Levels of IL-1 were undetectable in all but one sample. 3. 3|The IL-6 level peaked on day 3 of the infection, then decreased. The IL-6 levels were significantly associated with the duration of fever (P < 0.05) and the maximum body temperature (BT) (P < 0.05), but not with the BT at time of blood sampling, C-reactive protein levels or leukocyte counts. 4. 4|Levels of G-CSF were slightly higher in the patients with infection than in the controls (P < 0.05), but were not correlated with any other parameter including neutrophil counts. 5. 5|These cytokine levels neither reflected a differing T-serotype infection, nor did they vary among patients with regard to the presence of skin eruptions and the carrier state. 6. 6|These observations suggest that IL-6, but not IL-1, is produced during the acute phase of GABHS infection, accounting for the febrile condition as an inflammatory cytokine, despite the serotype of the infecting organism or the clinical types of infection.

Original languageEnglish
Pages (from-to)91-96
Number of pages6
JournalJournal of Thermal Biology
Issue number2
Publication statusPublished - Apr 1994

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Agricultural and Biological Sciences(all)
  • Developmental Biology


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