Association between heart rate variability, blood pressure and autonomic activity in cyclic alternating pattern during sleep

Hideaki Kondo, Motohiro Ozone, Noboru Ohki, Yohei Sagawa, Keiichirou Yamamichi, Mitsuki Fukuju, Takeshi Yoshida, Chikako Nishi, Akiko Kawasaki, Kaori Mori, Takashi Kanbayashi, Motomori Izumi, Yasuo Hishikawa, Seiji Nishino, Tetsuo Shimizu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Study Objectives: Cyclic alternating pattern (CAP) is frequently followed by changes in heart rate (HR) and blood pressure (BP), but the sequential associations between CAP and autonomic nerve activity have not been studied. The study aimed to reveal the precise changes in heart rate variability (HRV) during phase A of the CAP cycle. Design: Polysomnography was recorded according to the CAP Atlas (Terzano, 2002), and BP and electrocardiogram were simultaneously recorded. The complex demodulation method was used for analysis of HRV and evaluation of autonomic nerve activity. Setting: Academic sleep laboratory. Participants: Ten healthy males. Measurements and Results: The increase in HR (median [first quartile - third quartile]) for each subtype was as follows: A1, 0.64 (-0.30 to 1.69), A2, 1.44 (0.02 to 3.79), and A3, 6.24 (2.53 to 10.76) bpm (A1 vs. A2 P 0.001, A1 vs. A3 P 0.001, A2 vs. A3 P 0.001). The increase in BP for each subtype was as follows: A1, 1.23 (-2.04 to 5.75), A2, 1.76 (-1.46 to 9.32), and A3, 12.51 (4.75 to 19.94) mm Hg (A1 vs. A2 P = 0.249, A1 vs. A3 P 0.001, A2 vs. A3 P 0.001). In all of phase A, the peak values for HR and BP appeared at 4.2 (3.5 to 5.4) and 8.4 (7.0 to 10.3) seconds, respectively, after the onset of phase A. The area under the curve for low-frequency and high-frequency amplitude significantly increased after the onset of CAP phase A (P 0.001) and was higher in the order of subtype A3, A2, and A1 (P 0.001 ). Conclusions: All phase A subtypes were accompanied with increased heart rate variability, and the largest heart rate variability was seen in subtype A3, while a tendency for less heart rate variability was seen in subtype A1.

Original languageEnglish
Pages (from-to)187-194
Number of pages8
JournalSleep
Volume37
Issue number1
DOIs
Publication statusPublished - Jan 1 2014

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varespladib methyl
Sleep
Heart Rate
Blood Pressure
Autonomic Pathways
Polysomnography
Atlases
Area Under Curve
Healthy Volunteers
Electrocardiography

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Physiology (medical)

Cite this

Kondo, H., Ozone, M., Ohki, N., Sagawa, Y., Yamamichi, K., Fukuju, M., ... Shimizu, T. (2014). Association between heart rate variability, blood pressure and autonomic activity in cyclic alternating pattern during sleep. Sleep, 37(1), 187-194. https://doi.org/10.5665/sleep.3334

Association between heart rate variability, blood pressure and autonomic activity in cyclic alternating pattern during sleep. / Kondo, Hideaki; Ozone, Motohiro; Ohki, Noboru; Sagawa, Yohei; Yamamichi, Keiichirou; Fukuju, Mitsuki; Yoshida, Takeshi; Nishi, Chikako; Kawasaki, Akiko; Mori, Kaori; Kanbayashi, Takashi; Izumi, Motomori; Hishikawa, Yasuo; Nishino, Seiji; Shimizu, Tetsuo.

In: Sleep, Vol. 37, No. 1, 01.01.2014, p. 187-194.

Research output: Contribution to journalArticle

Kondo, H, Ozone, M, Ohki, N, Sagawa, Y, Yamamichi, K, Fukuju, M, Yoshida, T, Nishi, C, Kawasaki, A, Mori, K, Kanbayashi, T, Izumi, M, Hishikawa, Y, Nishino, S & Shimizu, T 2014, 'Association between heart rate variability, blood pressure and autonomic activity in cyclic alternating pattern during sleep', Sleep, vol. 37, no. 1, pp. 187-194. https://doi.org/10.5665/sleep.3334
Kondo, Hideaki ; Ozone, Motohiro ; Ohki, Noboru ; Sagawa, Yohei ; Yamamichi, Keiichirou ; Fukuju, Mitsuki ; Yoshida, Takeshi ; Nishi, Chikako ; Kawasaki, Akiko ; Mori, Kaori ; Kanbayashi, Takashi ; Izumi, Motomori ; Hishikawa, Yasuo ; Nishino, Seiji ; Shimizu, Tetsuo. / Association between heart rate variability, blood pressure and autonomic activity in cyclic alternating pattern during sleep. In: Sleep. 2014 ; Vol. 37, No. 1. pp. 187-194.
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abstract = "Study Objectives: Cyclic alternating pattern (CAP) is frequently followed by changes in heart rate (HR) and blood pressure (BP), but the sequential associations between CAP and autonomic nerve activity have not been studied. The study aimed to reveal the precise changes in heart rate variability (HRV) during phase A of the CAP cycle. Design: Polysomnography was recorded according to the CAP Atlas (Terzano, 2002), and BP and electrocardiogram were simultaneously recorded. The complex demodulation method was used for analysis of HRV and evaluation of autonomic nerve activity. Setting: Academic sleep laboratory. Participants: Ten healthy males. Measurements and Results: The increase in HR (median [first quartile - third quartile]) for each subtype was as follows: A1, 0.64 (-0.30 to 1.69), A2, 1.44 (0.02 to 3.79), and A3, 6.24 (2.53 to 10.76) bpm (A1 vs. A2 P 0.001, A1 vs. A3 P 0.001, A2 vs. A3 P 0.001). The increase in BP for each subtype was as follows: A1, 1.23 (-2.04 to 5.75), A2, 1.76 (-1.46 to 9.32), and A3, 12.51 (4.75 to 19.94) mm Hg (A1 vs. A2 P = 0.249, A1 vs. A3 P 0.001, A2 vs. A3 P 0.001). In all of phase A, the peak values for HR and BP appeared at 4.2 (3.5 to 5.4) and 8.4 (7.0 to 10.3) seconds, respectively, after the onset of phase A. The area under the curve for low-frequency and high-frequency amplitude significantly increased after the onset of CAP phase A (P 0.001) and was higher in the order of subtype A3, A2, and A1 (P 0.001 ). Conclusions: All phase A subtypes were accompanied with increased heart rate variability, and the largest heart rate variability was seen in subtype A3, while a tendency for less heart rate variability was seen in subtype A1.",
author = "Hideaki Kondo and Motohiro Ozone and Noboru Ohki and Yohei Sagawa and Keiichirou Yamamichi and Mitsuki Fukuju and Takeshi Yoshida and Chikako Nishi and Akiko Kawasaki and Kaori Mori and Takashi Kanbayashi and Motomori Izumi and Yasuo Hishikawa and Seiji Nishino and Tetsuo Shimizu",
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AU - Kondo, Hideaki

AU - Ozone, Motohiro

AU - Ohki, Noboru

AU - Sagawa, Yohei

AU - Yamamichi, Keiichirou

AU - Fukuju, Mitsuki

AU - Yoshida, Takeshi

AU - Nishi, Chikako

AU - Kawasaki, Akiko

AU - Mori, Kaori

AU - Kanbayashi, Takashi

AU - Izumi, Motomori

AU - Hishikawa, Yasuo

AU - Nishino, Seiji

AU - Shimizu, Tetsuo

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N2 - Study Objectives: Cyclic alternating pattern (CAP) is frequently followed by changes in heart rate (HR) and blood pressure (BP), but the sequential associations between CAP and autonomic nerve activity have not been studied. The study aimed to reveal the precise changes in heart rate variability (HRV) during phase A of the CAP cycle. Design: Polysomnography was recorded according to the CAP Atlas (Terzano, 2002), and BP and electrocardiogram were simultaneously recorded. The complex demodulation method was used for analysis of HRV and evaluation of autonomic nerve activity. Setting: Academic sleep laboratory. Participants: Ten healthy males. Measurements and Results: The increase in HR (median [first quartile - third quartile]) for each subtype was as follows: A1, 0.64 (-0.30 to 1.69), A2, 1.44 (0.02 to 3.79), and A3, 6.24 (2.53 to 10.76) bpm (A1 vs. A2 P 0.001, A1 vs. A3 P 0.001, A2 vs. A3 P 0.001). The increase in BP for each subtype was as follows: A1, 1.23 (-2.04 to 5.75), A2, 1.76 (-1.46 to 9.32), and A3, 12.51 (4.75 to 19.94) mm Hg (A1 vs. A2 P = 0.249, A1 vs. A3 P 0.001, A2 vs. A3 P 0.001). In all of phase A, the peak values for HR and BP appeared at 4.2 (3.5 to 5.4) and 8.4 (7.0 to 10.3) seconds, respectively, after the onset of phase A. The area under the curve for low-frequency and high-frequency amplitude significantly increased after the onset of CAP phase A (P 0.001) and was higher in the order of subtype A3, A2, and A1 (P 0.001 ). Conclusions: All phase A subtypes were accompanied with increased heart rate variability, and the largest heart rate variability was seen in subtype A3, while a tendency for less heart rate variability was seen in subtype A1.

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