Association between IFNA genotype and the risk of systemic lupus erythematosus

Hitoshi Nakashima, Sawako Matsuno, Mitsuteru Akahoshi, Katsuhisa Miyake, Yasushi Inoue, Yosuke Tanaka, Ichiro Ninomiya, Sakiko Shimizu, Takashi Igawa, Atsushi Sadanaga, Takeshi Otsuka, Mine Harada

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Systemic lupus erythematosus (SLE) is characterized by multisystem inflammation and production of autoantibodies, which can generate immune complexes and may cause tissue damage through the recognition of an autoantigen. Although many factors have been proposed, such as genetic factors, environmental factors, hormonal action, viruses, and dysregulation of cytokine production, the cause of this disease is not well understood. It has been reported that the levels of interferon (IFN)-α in the sera of some SLE patients are elevated and that IFN-α induces maturation of monocytes into highly active antigen-presenting dendritic cells (DCs). We analyzed the association between IFN-α genotype and the risk of SLE to clarify whether IFN-α plays a central role in susceptibility to SLE. The results showed that no IFN-α genotype was significantly associated with the risk of SLE.

Original languageEnglish
Pages (from-to)38-40
Number of pages3
JournalClinical Rheumatology
Volume24
Issue number1
DOIs
Publication statusPublished - Feb 1 2005

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Systemic Lupus Erythematosus
Interferons
Genotype
Autoantigens
Antigen-Presenting Cells
Antigen-Antibody Complex
Autoantibodies
Dendritic Cells
Monocytes
Cytokines
Viruses
Inflammation
Serum

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

Nakashima, H., Matsuno, S., Akahoshi, M., Miyake, K., Inoue, Y., Tanaka, Y., ... Harada, M. (2005). Association between IFNA genotype and the risk of systemic lupus erythematosus. Clinical Rheumatology, 24(1), 38-40. https://doi.org/10.1007/s10067-004-0966-8

Association between IFNA genotype and the risk of systemic lupus erythematosus. / Nakashima, Hitoshi; Matsuno, Sawako; Akahoshi, Mitsuteru; Miyake, Katsuhisa; Inoue, Yasushi; Tanaka, Yosuke; Ninomiya, Ichiro; Shimizu, Sakiko; Igawa, Takashi; Sadanaga, Atsushi; Otsuka, Takeshi; Harada, Mine.

In: Clinical Rheumatology, Vol. 24, No. 1, 01.02.2005, p. 38-40.

Research output: Contribution to journalArticle

Nakashima, H, Matsuno, S, Akahoshi, M, Miyake, K, Inoue, Y, Tanaka, Y, Ninomiya, I, Shimizu, S, Igawa, T, Sadanaga, A, Otsuka, T & Harada, M 2005, 'Association between IFNA genotype and the risk of systemic lupus erythematosus', Clinical Rheumatology, vol. 24, no. 1, pp. 38-40. https://doi.org/10.1007/s10067-004-0966-8
Nakashima, Hitoshi ; Matsuno, Sawako ; Akahoshi, Mitsuteru ; Miyake, Katsuhisa ; Inoue, Yasushi ; Tanaka, Yosuke ; Ninomiya, Ichiro ; Shimizu, Sakiko ; Igawa, Takashi ; Sadanaga, Atsushi ; Otsuka, Takeshi ; Harada, Mine. / Association between IFNA genotype and the risk of systemic lupus erythematosus. In: Clinical Rheumatology. 2005 ; Vol. 24, No. 1. pp. 38-40.
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