Association between IL-4 genotype and IL-4 production in the Japanese population

H. Nakashima, K. Miyake, Y. Inoue, S. Shimizu, M. Akahoshi, Y. Tanaka, T. Otsuka, M. Harada

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117 Citations (Scopus)

Abstract

We have identified that there are only two IL-4 gene haplotypes (I and II) in the Japanese population. There are significant differences among three genotypes (I/I, I/II and II/II) in the IL-4 producing proportion of peripheral Th cells using intracellular cytokine detection assay. These results make it likely that IL-4 genotype could influence the type of immune response.

Original languageEnglish
Pages (from-to)107-109
Number of pages3
JournalGenes and Immunity
Volume3
Issue number2
DOIs
Publication statusPublished - Apr 2002

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics
  • Genetics(clinical)

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  • Cite this

    Nakashima, H., Miyake, K., Inoue, Y., Shimizu, S., Akahoshi, M., Tanaka, Y., Otsuka, T., & Harada, M. (2002). Association between IL-4 genotype and IL-4 production in the Japanese population. Genes and Immunity, 3(2), 107-109. https://doi.org/10.1038/sj.gene.6363830