Association between mental health and serum brain-derived neurotrophic factor in hemodialysis patients

Reiko Nishichi, Harumichi Higashi, Masakazu Washio, Kageshige Todo, Shuzo Kumagai

Research output: Contribution to journalArticle

Abstract

Purpose: To clarify the association between the serum BDNF levels and the mental health status in HD patients. Design: Cross sectional study. Subjects and Methods: Seventy-seven Hemodialysis (HD) patients and 14 healthy subjects completed the 30-item version of the Japanese General Health Questionnaire (GHQ-30) and were assessed in regard to their serum BDNF content. Results: A significant negative correlation was observed between the GHQ-30 score and the serum BDNF level (r = - 0.34, p > 0.01) in all subjects. The serum BDNF level in the HD patients was significantly lower than that in the healthy subjects. The mean serum BDNF in the psychiatric distress group was significantly lower than that in the non-psychiatric distress group among the HD patients (OR = 4.78: 95% CI = 1.46-15.61). Conclusion: The mental health status in HD patients is therefore considered to be associated with lower serum BDNF levels, and this factor may be connected with the risk factors for arteriosclerosis, including insulin resistance, hyperglycemia, and dyslipidemia.

Original languageEnglish
Pages (from-to)114-116
Number of pages3
JournalInternational Medical Journal
Volume18
Issue number2
Publication statusPublished - Jun 1 2011

Fingerprint

Mental Health Associations
Brain-Derived Neurotrophic Factor
Renal Dialysis
Serum
Health Status
Healthy Volunteers
Mental Health
Arteriosclerosis
Dyslipidemias
Hyperglycemia
Psychiatry
Insulin Resistance
Cross-Sectional Studies
Health

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Association between mental health and serum brain-derived neurotrophic factor in hemodialysis patients. / Nishichi, Reiko; Higashi, Harumichi; Washio, Masakazu; Todo, Kageshige; Kumagai, Shuzo.

In: International Medical Journal, Vol. 18, No. 2, 01.06.2011, p. 114-116.

Research output: Contribution to journalArticle

Nishichi, Reiko ; Higashi, Harumichi ; Washio, Masakazu ; Todo, Kageshige ; Kumagai, Shuzo. / Association between mental health and serum brain-derived neurotrophic factor in hemodialysis patients. In: International Medical Journal. 2011 ; Vol. 18, No. 2. pp. 114-116.
@article{ef9a621414fa4cda960930914f7480cf,
title = "Association between mental health and serum brain-derived neurotrophic factor in hemodialysis patients",
abstract = "Purpose: To clarify the association between the serum BDNF levels and the mental health status in HD patients. Design: Cross sectional study. Subjects and Methods: Seventy-seven Hemodialysis (HD) patients and 14 healthy subjects completed the 30-item version of the Japanese General Health Questionnaire (GHQ-30) and were assessed in regard to their serum BDNF content. Results: A significant negative correlation was observed between the GHQ-30 score and the serum BDNF level (r = - 0.34, p > 0.01) in all subjects. The serum BDNF level in the HD patients was significantly lower than that in the healthy subjects. The mean serum BDNF in the psychiatric distress group was significantly lower than that in the non-psychiatric distress group among the HD patients (OR = 4.78: 95{\%} CI = 1.46-15.61). Conclusion: The mental health status in HD patients is therefore considered to be associated with lower serum BDNF levels, and this factor may be connected with the risk factors for arteriosclerosis, including insulin resistance, hyperglycemia, and dyslipidemia.",
author = "Reiko Nishichi and Harumichi Higashi and Masakazu Washio and Kageshige Todo and Shuzo Kumagai",
year = "2011",
month = "6",
day = "1",
language = "English",
volume = "18",
pages = "114--116",
journal = "International Medical Journal",
issn = "1341-2051",
publisher = "Japan International Cultural Exchange Foundation",
number = "2",

}

TY - JOUR

T1 - Association between mental health and serum brain-derived neurotrophic factor in hemodialysis patients

AU - Nishichi, Reiko

AU - Higashi, Harumichi

AU - Washio, Masakazu

AU - Todo, Kageshige

AU - Kumagai, Shuzo

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Purpose: To clarify the association between the serum BDNF levels and the mental health status in HD patients. Design: Cross sectional study. Subjects and Methods: Seventy-seven Hemodialysis (HD) patients and 14 healthy subjects completed the 30-item version of the Japanese General Health Questionnaire (GHQ-30) and were assessed in regard to their serum BDNF content. Results: A significant negative correlation was observed between the GHQ-30 score and the serum BDNF level (r = - 0.34, p > 0.01) in all subjects. The serum BDNF level in the HD patients was significantly lower than that in the healthy subjects. The mean serum BDNF in the psychiatric distress group was significantly lower than that in the non-psychiatric distress group among the HD patients (OR = 4.78: 95% CI = 1.46-15.61). Conclusion: The mental health status in HD patients is therefore considered to be associated with lower serum BDNF levels, and this factor may be connected with the risk factors for arteriosclerosis, including insulin resistance, hyperglycemia, and dyslipidemia.

AB - Purpose: To clarify the association between the serum BDNF levels and the mental health status in HD patients. Design: Cross sectional study. Subjects and Methods: Seventy-seven Hemodialysis (HD) patients and 14 healthy subjects completed the 30-item version of the Japanese General Health Questionnaire (GHQ-30) and were assessed in regard to their serum BDNF content. Results: A significant negative correlation was observed between the GHQ-30 score and the serum BDNF level (r = - 0.34, p > 0.01) in all subjects. The serum BDNF level in the HD patients was significantly lower than that in the healthy subjects. The mean serum BDNF in the psychiatric distress group was significantly lower than that in the non-psychiatric distress group among the HD patients (OR = 4.78: 95% CI = 1.46-15.61). Conclusion: The mental health status in HD patients is therefore considered to be associated with lower serum BDNF levels, and this factor may be connected with the risk factors for arteriosclerosis, including insulin resistance, hyperglycemia, and dyslipidemia.

UR - http://www.scopus.com/inward/record.url?scp=79960527063&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960527063&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:79960527063

VL - 18

SP - 114

EP - 116

JO - International Medical Journal

JF - International Medical Journal

SN - 1341-2051

IS - 2

ER -