Abstract
Purpose: To clarify the association between the serum BDNF levels and the mental health status in HD patients. Design: Cross sectional study. Subjects and Methods: Seventy-seven Hemodialysis (HD) patients and 14 healthy subjects completed the 30-item version of the Japanese General Health Questionnaire (GHQ-30) and were assessed in regard to their serum BDNF content. Results: A significant negative correlation was observed between the GHQ-30 score and the serum BDNF level (r = - 0.34, p > 0.01) in all subjects. The serum BDNF level in the HD patients was significantly lower than that in the healthy subjects. The mean serum BDNF in the psychiatric distress group was significantly lower than that in the non-psychiatric distress group among the HD patients (OR = 4.78: 95% CI = 1.46-15.61). Conclusion: The mental health status in HD patients is therefore considered to be associated with lower serum BDNF levels, and this factor may be connected with the risk factors for arteriosclerosis, including insulin resistance, hyperglycemia, and dyslipidemia.
| Original language | English |
|---|---|
| Pages (from-to) | 114-116 |
| Number of pages | 3 |
| Journal | International Medical Journal |
| Volume | 18 |
| Issue number | 2 |
| Publication status | Published - Jun 1 2011 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Association between mental health and serum brain-derived neurotrophic factor in hemodialysis patients. / Nishichi, Reiko; Higashi, Harumichi; Washio, Masakazu; Todo, Kageshige; Kumagai, Shuzo.
In: International Medical Journal, Vol. 18, No. 2, 01.06.2011, p. 114-116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between mental health and serum brain-derived neurotrophic factor in hemodialysis patients
AU - Nishichi, Reiko
AU - Higashi, Harumichi
AU - Washio, Masakazu
AU - Todo, Kageshige
AU - Kumagai, Shuzo
PY - 2011/6/1
Y1 - 2011/6/1
N2 - Purpose: To clarify the association between the serum BDNF levels and the mental health status in HD patients. Design: Cross sectional study. Subjects and Methods: Seventy-seven Hemodialysis (HD) patients and 14 healthy subjects completed the 30-item version of the Japanese General Health Questionnaire (GHQ-30) and were assessed in regard to their serum BDNF content. Results: A significant negative correlation was observed between the GHQ-30 score and the serum BDNF level (r = - 0.34, p > 0.01) in all subjects. The serum BDNF level in the HD patients was significantly lower than that in the healthy subjects. The mean serum BDNF in the psychiatric distress group was significantly lower than that in the non-psychiatric distress group among the HD patients (OR = 4.78: 95% CI = 1.46-15.61). Conclusion: The mental health status in HD patients is therefore considered to be associated with lower serum BDNF levels, and this factor may be connected with the risk factors for arteriosclerosis, including insulin resistance, hyperglycemia, and dyslipidemia.
AB - Purpose: To clarify the association between the serum BDNF levels and the mental health status in HD patients. Design: Cross sectional study. Subjects and Methods: Seventy-seven Hemodialysis (HD) patients and 14 healthy subjects completed the 30-item version of the Japanese General Health Questionnaire (GHQ-30) and were assessed in regard to their serum BDNF content. Results: A significant negative correlation was observed between the GHQ-30 score and the serum BDNF level (r = - 0.34, p > 0.01) in all subjects. The serum BDNF level in the HD patients was significantly lower than that in the healthy subjects. The mean serum BDNF in the psychiatric distress group was significantly lower than that in the non-psychiatric distress group among the HD patients (OR = 4.78: 95% CI = 1.46-15.61). Conclusion: The mental health status in HD patients is therefore considered to be associated with lower serum BDNF levels, and this factor may be connected with the risk factors for arteriosclerosis, including insulin resistance, hyperglycemia, and dyslipidemia.
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M3 - Article
AN - SCOPUS:79960527063
VL - 18
SP - 114
EP - 116
JO - International Medical Journal
JF - International Medical Journal
SN - 1341-2051
IS - 2
ER -